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Methylation of hypoxia-inducible factor (HIF)-1α by G9a/GLP inhibits HIF-1 transcriptional activity and cell migration.
Bao, Lei; Chen, Yan; Lai, Hsien-Tsung; Wu, Shwu-Yuan; Wang, Jennifer E; Hatanpaa, Kimmo J; Raisanen, Jack M; Fontenot, Miles; Lega, Bradley; Chiang, Cheng-Ming; Semenza, Gregg L; Wang, Yingfei; Luo, Weibo.
Affiliation
  • Bao L; Department of Pathology, UT Southwestern Medical Center, Dallas, TX 75390, USA.
  • Chen Y; Department of Pathology, UT Southwestern Medical Center, Dallas, TX 75390, USA.
  • Lai HT; Simmons Comprehensive Cancer Center, UT Southwestern Medical Center, Dallas, TX 75390, USA.
  • Wu SY; Simmons Comprehensive Cancer Center, UT Southwestern Medical Center, Dallas, TX 75390, USA.
  • Wang JE; Department of Biochemistry, UT Southwestern Medical Center, Dallas, TX 75390, USA.
  • Hatanpaa KJ; Department of Pathology, UT Southwestern Medical Center, Dallas, TX 75390, USA.
  • Raisanen JM; Department of Pathology, UT Southwestern Medical Center, Dallas, TX 75390, USA.
  • Fontenot M; Department of Pathology, UT Southwestern Medical Center, Dallas, TX 75390, USA.
  • Lega B; Medical Scientist Training Program, UT Southwestern Medical Center, Dallas, TX 75390, USA.
  • Chiang CM; Department of Neurological Surgery, UT Southwestern Medical Center, Dallas, TX 75390, USA.
  • Semenza GL; Simmons Comprehensive Cancer Center, UT Southwestern Medical Center, Dallas, TX 75390, USA.
  • Wang Y; Department of Biochemistry, UT Southwestern Medical Center, Dallas, TX 75390, USA.
  • Luo W; Department of Pharmacology, UT Southwestern Medical Center, Dallas, TX 75390, USA.
Nucleic Acids Res ; 46(13): 6576-6591, 2018 07 27.
Article in En | MEDLINE | ID: mdl-29860315
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Full text: 1 Database: MEDLINE Main subject: Autoantigens / Transcription, Genetic / Gene Expression Regulation, Neoplastic / Histone-Lysine N-Methyltransferase / Glioblastoma / Epigenesis, Genetic / Hypoxia-Inducible Factor 1, alpha Subunit / Golgi Matrix Proteins / Histocompatibility Antigens Limits: Humans Language: En Year: 2018 Type: Article
Fulltext
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Full text: 1 Database: MEDLINE Main subject: Autoantigens / Transcription, Genetic / Gene Expression Regulation, Neoplastic / Histone-Lysine N-Methyltransferase / Glioblastoma / Epigenesis, Genetic / Hypoxia-Inducible Factor 1, alpha Subunit / Golgi Matrix Proteins / Histocompatibility Antigens Limits: Humans Language: En Year: 2018 Type: Article