Structures of REV1 UBM2 Domain Complex with Ubiquitin and with a Small-Molecule that Inhibits the REV1 UBM2-Ubiquitin Interaction.

Vanarotti, Murugendra; Grace, Christy R; Miller, Darcie J; Actis, Marcelo L; Inoue, Akira; Evison, Benjamin J; Vaithiyalingam, Sivaraja; Singh, Aman P; McDonald, Ezelle T; Fujii, Naoaki

Vanarotti, Murugendra; Grace, Christy R; Miller, Darcie J; Actis, Marcelo L; Inoue, Akira; Evison, Benjamin J; Vaithiyalingam, Sivaraja; Singh, Aman P; McDonald, Ezelle T; Fujii, Naoaki.

Affiliation

Vanarotti M; Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, TN 38105, USA. Electronic address: murugendra.vanarotti@stjude.org.
Grace CR; Department of Structural Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Miller DJ; Department of Structural Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Actis ML; Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Inoue A; Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Evison BJ; Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Vaithiyalingam S; Department of Molecular Interaction Analysis Shared Resource, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Singh AP; Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
McDonald ET; Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Fujii N; Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, TN 38105, USA. Electronic address: naoaki.fujii@gmail.com.

J Mol Biol ; 430(17): 2857-2872, 2018 08 17.

Article in En | MEDLINE | ID: mdl-29864443

Subject(s)

Nuclear Proteins/chemistry; Nuclear Proteins/metabolism; Nucleotidyltransferases/chemistry; Nucleotidyltransferases/metabolism; Phenyl Ethers/pharmacology; Small Molecule Libraries/pharmacology; Ubiquitin/chemistry; Ubiquitin/metabolism; Amino Acid Sequence; Bone Neoplasms/metabolism; Bone Neoplasms/pathology; Chromatin/chemistry; Crystallography, X-Ray; DNA/chemistry; DNA/metabolism; DNA Damage; Humans; Models, Molecular; Nuclear Proteins/drug effects; Nucleotidyltransferases/drug effects; Osteosarcoma/metabolism; Osteosarcoma/pathology; Protein Binding; Protein Conformation; Protein Domains; Tumor Cells, Cultured; Ubiquitin/drug effects; Ubiquitination

Key words

crystallography; inhibitor; protein NMR; proteinprotein interaction; ubiquitin-binding motif

Fulltext

XML

PubMed Links

Search on Google

Full text: 1 Database: MEDLINE Main subject: Phenyl Ethers / Nuclear Proteins / Ubiquitin / Small Molecule Libraries / Nucleotidyltransferases Type of study: Prognostic_studies Limits: Humans Language: En Year: 2018 Type: Article

Fulltext

XML

PubMed Links

Search on Google