Ultraviolet radiation augments epidermal beta-adrenergic adenylate cyclase response.
J Invest Dermatol
; 84(5): 401-3, 1985 May.
Article
in En
| MEDLINE
| ID: mdl-2987360
ABSTRACT
Pig skin was irradiated in vivo with fluorescent sunlamp tubes (peak emission at 305 nm). A significant increase in epidermal beta-adrenergic adenylate cyclase response was observed as early as 12 h following 1-2 minimum erythema doses (MEDs) UVB exposure, which lasted at least 48 h. The augmentation of adenylate cyclase response was relatively specific to the beta-adrenergic system and there was no significant difference in either adenosine- or histamine-adenylate cyclase response of epidermis. The increased beta-adrenergic adenylate cyclase response was less marked at higher doses of UVB exposure (5 MEDs); in the latter condition, a significant reduction in adenosine- or histamine-adenylate cyclase response was observed. There was no significant difference in either low- or high-Km cyclic AMP phosphodiesterase activity between control and UVB-treated skin at 1-2 MEDs. Our data indicate that the epidermal adenylate cyclase responses are affected in vivo by UVB irradiation, which might be a significant regulatory mechanism of epidermal cyclic AMP systems.
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Database:
MEDLINE
Main subject:
Ultraviolet Rays
/
Adenylyl Cyclases
/
Receptors, Adrenergic
/
Epidermis
Limits:
Animals
Language:
En
Year:
1985
Type:
Article