Lymph node evaluation in high-risk early stage endometrial cancer: A multi-institutional retrospective analysis comparing the sentinel lymph node (SLN) algorithm and SLN with selective lymphadenectomy.
Gynecol Oncol
; 150(2): 261-266, 2018 08.
Article
in En
| MEDLINE
| ID: mdl-29887483
ABSTRACT
OBJECTIVE:
The aim of this study was to determine the impact of the sentinel lymph node mapping algorithm (SLN-A) on the staging in high-risk endometrial cancer (EC) compared to SLN plus selective lymphadenectomy (S-LND).METHODS:
We retrospectively analyzed the database from a multicenter collaboration that included women with high risk features who underwent primary surgical staging.RESULTS:
One-hundred and seventy-one women were identified (171), 66 in the SLN-A and 105 in the S-LND group, respectively. Pelvic LD was performed on 115 patients (67.2%) and aortic dissection was performed in 54/105 of the women in the S-LND group (51%). The 5-year comparison did not show a significant difference in the strategy adopted for nodal staging, regarding disease-free survival (DFS) [HR 0.82; 95% CI 0.53-1.28; pâ¯=â¯0.390].CONCLUSIONS:
In this study focusing on women with EC in the HR groups, we did not find a difference in the 5-year DFS when comparing the SLN-A strategy with S-LND. The SLN strategy did not seem to compromise the prognosis of patients with a higher risk of recurrence.Key words
Full text:
1
Database:
MEDLINE
Main subject:
Endometrial Neoplasms
/
Sentinel Lymph Node
Type of study:
Etiology_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limits:
Adult
/
Aged
/
Aged80
/
Female
/
Humans
/
Middle aged
Language:
En
Year:
2018
Type:
Article