Hyperphosphorylation of protein Tau in hippocampus may cause cognitive dysfunction of propofol-anesthetized rats.

Zheng, H-B; Fu, Y-T; Wang, G; Sun, L-H; Fan, Y-Y; Yang, T-W

Zheng, H-B; Fu, Y-T; Wang, G; Sun, L-H; Fan, Y-Y; Yang, T-W.

Affiliation

Zheng HB; Department of Anesthesiology, The Second Hospital of Jilin University, Changchun, China. Yantaofu@163.com.

Eur Rev Med Pharmacol Sci ; 22(11): 3577-3585, 2018 06.

Article in En | MEDLINE | ID: mdl-29917212

Subject(s)

Anesthetics, Intravenous/pharmacology; Cognitive Dysfunction/pathology; Hippocampus/metabolism; Propofol/pharmacology; tau Proteins/metabolism; Animals; Caspase 3/genetics; Caspase 3/metabolism; Cognitive Dysfunction/metabolism; Cyclin D1/genetics; Cyclin D1/metabolism; Glycogen Synthase Kinase 3 beta/genetics; Glycogen Synthase Kinase 3 beta/metabolism; Male; Maze Learning/drug effects; Phosphorylation/drug effects; Rats; Rats, Wistar

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Full text: 1 Database: MEDLINE Main subject: Propofol / Tau Proteins / Anesthetics, Intravenous / Cognitive Dysfunction / Hippocampus Limits: Animals Language: En Year: 2018 Type: Article

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