Synthesis and cholinesterase inhibitory activity of new 2-benzofuran carboxamide-benzylpyridinum salts.

Abedinifar, Fahimeh; Farnia, S Morteza F; Mahdavi, Mohammad; Nadri, Hamid; Moradi, Alireza; Ghasemi, Jahan B; Küçükkilinç, Tuba Tüylü; Firoozpour, Loghman; Foroumadi, Alireza

Abedinifar, Fahimeh; Farnia, S Morteza F; Mahdavi, Mohammad; Nadri, Hamid; Moradi, Alireza; Ghasemi, Jahan B; Küçükkilinç, Tuba Tüylü; Firoozpour, Loghman; Foroumadi, Alireza.

Affiliation

Abedinifar F; School of Chemistry, College of Science, University of Tehran, Tehran, Iran.
Farnia SMF; School of Chemistry, College of Science, University of Tehran, Tehran, Iran. Electronic address: mfarnia@khayam.ut.ac.ir.
Mahdavi M; Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.
Nadri H; Department of Medicinal Chemistry, Faculty of Pharmacy, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Moradi A; Department of Medicinal Chemistry, Faculty of Pharmacy, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Ghasemi JB; School of Chemistry, College of Science, University of Tehran, Tehran, Iran.
Küçükkilinç TT; Department of Biochemistry, Faculty of Pharmacy, Hacettepe University, Ankara, Turkey.
Firoozpour L; Department of Medicinal Chemistry, Faculty of Pharmacy and The Institute of Pharmaceutical Sciences (TIPS), Tehran University of Medical Sciences, Tehran, Iran.
Foroumadi A; Department of Medicinal Chemistry, Faculty of Pharmacy and The Institute of Pharmaceutical Sciences (TIPS), Tehran University of Medical Sciences, Tehran, Iran; Department of Medicinal Chemistry, Faculty of Pharmacy and Neuroscience Research Center, Institute of Neuropharmacology, Kerman University

Bioorg Chem ; 80: 180-188, 2018 10.

Article in En | MEDLINE | ID: mdl-29929079

Subject(s)

Acetylcholinesterase/metabolism; Butyrylcholinesterase/metabolism; Cholinesterase Inhibitors/chemical synthesis; Pyridines/chemistry; Acetylcholinesterase/chemistry; Amides/chemistry; Amyloid beta-Peptides/chemistry; Amyloid beta-Peptides/metabolism; Benzofurans/chemistry; Binding Sites; Butyrylcholinesterase/chemistry; Catalytic Domain; Cholinesterase Inhibitors/metabolism; Drug Design; Molecular Docking Simulation; Pyridines/metabolism; Salts/chemistry; Structure-Activity Relationship

Key words

Alzheimer's disease; Benzofuran-2-carboxamide; Benzylpyridinium; Cholinesterase inhibitor

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Full text: 1 Database: MEDLINE Main subject: Acetylcholinesterase / Pyridines / Butyrylcholinesterase / Cholinesterase Inhibitors Language: En Year: 2018 Type: Article

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Full text: 1 Database: MEDLINE Main subject: Acetylcholinesterase / Pyridines / Butyrylcholinesterase / Cholinesterase Inhibitors Language: En Year: 2018 Type: Article