The Discovery of the Antiviral Resistance Gene Mx: A Story of Great Ideas, Great Failures, and Some Success.
Annu Rev Virol
; 5(1): 33-51, 2018 09 29.
Article
in En
| MEDLINE
| ID: mdl-29958082
ABSTRACT
The discovery of the Mx gene-dependent, innate resistance of mice against influenza virus was a matter of pure chance. Although the subsequent analysis of this antiviral resistance was guided by straightforward logic, it nevertheless led us into many blind alleys and was full of surprising turns and twists. Unexpectedly, this research resulted in the identification of one of the first interferon-stimulated genes and provided a new view of interferon action. It also showed that in many species, MX proteins have activities against a broad range of viruses. To this day, Mx research continues to flourish and to provide insights into the never-ending battle between viruses and their hosts.
Key words
Full text:
1
Database:
MEDLINE
Main subject:
Viruses
/
Biomedical Research
/
Disease Resistance
/
Myxovirus Resistance Proteins
/
Immunity, Innate
Type of study:
Prognostic_studies
Limits:
Animals
/
Humans
Language:
En
Year:
2018
Type:
Article