Aporphine Alkaloids from Illigera aromatica from Guangxi Province, China.
Phytochemistry
; 154: 73-76, 2018 Oct.
Article
in En
| MEDLINE
| ID: mdl-30006090
ABSTRACT
Three undescribed aporphine alkaloids laurodionine B (1), illigerine A (2), and N-formyl-laurolitsine (3) were isolated from the methanolic extracts of the Chinese medicinal plant, Illigera aromatica, together with three known analogues (4-6). The chemical structures of 1-6 were identified by spectroscopic methods including 1D and 2D NMR (1H, 13C, COSY, HSQC, and HMBC) and high resolution mass spectrometry (HRESIMS). Compounds 1-3 showed moderate inhibitory activities in vitro against two cultured tumor cell lines, Hela and SMMC7721, with IC50 values of 32.42-62.90⯵M. Only compound 1 had in vitro cytotoxic activity against Bcap37â¯cells, with the IC50 value of 90.61⯵M.
Key words
Full text:
1
Database:
MEDLINE
Main subject:
Aporphines
/
Drugs, Chinese Herbal
/
Hernandiaceae
/
Antineoplastic Agents, Phytogenic
Type of study:
Diagnostic_studies
Limits:
Humans
Country/Region as subject:
Asia
Language:
En
Year:
2018
Type:
Article