Multi-omics monitoring of drug response in rheumatoid arthritis in pursuit of molecular remission.
Nat Commun
; 9(1): 2755, 2018 07 16.
Article
in En
| MEDLINE
| ID: mdl-30013029
ABSTRACT
Sustained clinical remission (CR) without drug treatment has not been achieved in patients with rheumatoid arthritis (RA). This implies a substantial difference between CR and the healthy state, but it has yet to be quantified. We report a longitudinal monitoring of the drug response at multi-omics levels in the peripheral blood of patients with RA. Our data reveal that drug treatments alter the molecular profile closer to that of HCs at the transcriptome, serum proteome, and immunophenotype level. Patient follow-up suggests that the molecular profile after drug treatments is associated with long-term stable CR. In addition, we identify molecular signatures that are resistant to drug treatments. These signatures are associated with RA independently of known disease severity indexes and are largely explained by the imbalance of neutrophils, monocytes, and lymphocytes. This high-dimensional phenotyping provides a quantitative measure of molecular remission and illustrates a multi-omics approach to understanding drug response.
Full text:
1
Database:
MEDLINE
Main subject:
Arthritis, Rheumatoid
/
Blood Proteins
/
Methotrexate
/
Antirheumatic Agents
/
Transcriptome
Type of study:
Observational_studies
/
Risk_factors_studies
Limits:
Humans
Language:
En
Year:
2018
Type:
Article