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Resistance to Radiotherapy and PD-L1 Blockade Is Mediated by TIM-3 Upregulation and Regulatory T-Cell Infiltration.
Oweida, Ayman; Hararah, Mohammad K; Phan, Andy; Binder, David; Bhatia, Shilpa; Lennon, Shelby; Bukkapatnam, Sanjana; Van Court, Benjamin; Uyanga, Nomin; Darragh, Laurel; Kim, Hyun Min; Raben, David; Tan, Aik Choon; Heasley, Lynn; Clambey, Eric; Nemenoff, Raphael; Karam, Sana D.
Affiliation
  • Oweida A; Department of Radiation Oncology, University of Colorado Denver, Aurora, Colorado.
  • Hararah MK; Department of Otolaryngology and Head and Neck Surgery, University of Colorado Denver - Anschutz Medical Campus, Aurora, Colorado.
  • Phan A; Department of Radiation Oncology, University of Colorado Denver, Aurora, Colorado.
  • Binder D; Department of Radiation Oncology, University of Colorado Denver, Aurora, Colorado.
  • Bhatia S; Department of Radiation Oncology, University of Colorado Denver, Aurora, Colorado.
  • Lennon S; Department of Radiation Oncology, University of Colorado Denver, Aurora, Colorado.
  • Bukkapatnam S; Department of Radiation Oncology, University of Colorado Denver, Aurora, Colorado.
  • Van Court B; Department of Radiation Oncology, University of Colorado Denver, Aurora, Colorado.
  • Uyanga N; Department of Radiation Oncology, University of Colorado Denver, Aurora, Colorado.
  • Darragh L; Department of Radiation Oncology, University of Colorado Denver, Aurora, Colorado.
  • Kim HM; Division of Medical Oncology, University of Colorado Denver, Aurora, Colorado.
  • Raben D; Department of Radiation Oncology, University of Colorado Denver, Aurora, Colorado.
  • Tan AC; Division of Medical Oncology, University of Colorado Denver, Aurora, Colorado.
  • Heasley L; Department of Craniofacial Biology, University of Colorado Denver, Aurora, Colorado.
  • Clambey E; Department of Anesthesiology, University of Colorado Denver, Aurora, Colorado.
  • Nemenoff R; Department of Medicine, University of Colorado Denver, Aurora, Colorado.
  • Karam SD; Department of Radiation Oncology, University of Colorado Denver, Aurora, Colorado. sana.karam@ucdenver.edu.
Clin Cancer Res ; 24(21): 5368-5380, 2018 11 01.
Article in En | MEDLINE | ID: mdl-30042205
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Full text: 1 Database: MEDLINE Main subject: Radiation Tolerance / Lymphocytes, Tumor-Infiltrating / T-Lymphocytes, Regulatory / B7-H1 Antigen / Hepatitis A Virus Cellular Receptor 2 / Antineoplastic Agents, Immunological Limits: Animals / Humans Language: En Year: 2018 Type: Article
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Full text: 1 Database: MEDLINE Main subject: Radiation Tolerance / Lymphocytes, Tumor-Infiltrating / T-Lymphocytes, Regulatory / B7-H1 Antigen / Hepatitis A Virus Cellular Receptor 2 / Antineoplastic Agents, Immunological Limits: Animals / Humans Language: En Year: 2018 Type: Article