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The somatic proteins of Toxocara canis larvae and excretory-secretory products revealed by proteomics.
da Silva, Márcia B; Urrego A, Juan R; Oviedo, Yisela; Cooper, Philip J; Pacheco, Luis G C; Pinheiro, Carina S; Ferreira, Fátima; Briza, Peter; Alcantara-Neves, Neuza M.
Affiliation
  • da Silva MB; Instituto de Ciências da Saúde, Universidade Federal da Bahia, Salvador, Bahia, Brazil. Electronic address: marciasilva25j@yahoo.com.br.
  • Urrego A JR; Instituto de Ciências da Saúde, Universidade Federal da Bahia, Salvador, Bahia, Brazil; Department of Pharmaceutical Sciences, University of Cartagena, Cartagena, Colombia. Electronic address: ricardo_urrego@hotmail.com.
  • Oviedo Y; Instituto de Ciências da Saúde, Universidade Federal da Bahia, Salvador, Bahia, Brazil. Electronic address: goviv1@yahoo.com.
  • Cooper PJ; Facultad de Ciencias Médicas, de la Salud y la Vida, Universidad Internacional del Ecuador, Quito, Ecuador; Insitute of Infection and Immunity, St George's University of London, London, United Kingdom. Electronic address: pcooper@sgul.ac.uk.
  • Pacheco LGC; Instituto de Ciências da Saúde, Universidade Federal da Bahia, Salvador, Bahia, Brazil. Electronic address: lgcpacheco@gmail.com.
  • Pinheiro CS; Instituto de Ciências da Saúde, Universidade Federal da Bahia, Salvador, Bahia, Brazil. Electronic address: carinasilvapinheiro@gmail.com.
  • Ferreira F; Department of Biosciences, University of Salzburg, Salzburg, Austria. Electronic address: fatima.ferreira-briza@sbg.ac.at.
  • Briza P; Department of Biosciences, University of Salzburg, Salzburg, Austria. Electronic address: peter.briza@sbg.ac.at.
  • Alcantara-Neves NM; Instituto de Ciências da Saúde, Universidade Federal da Bahia, Salvador, Bahia, Brazil. Electronic address: neuza@ufba.br.
Vet Parasitol ; 259: 25-34, 2018 Aug 15.
Article in En | MEDLINE | ID: mdl-30056980
ABSTRACT
Toxocariasis is a widespread helminth infection of dogs and cats, caused by Toxocara canis and Toxocara cati larvae, respectively. Toxocara spp. can cause zoonotic infections in humans by invading tissues and organs causing pathology. Toxocara spp. larvae release excretory-secretory molecules (TES) into the body of their host that are fundamental to the host-parasite interaction and could be used as targets for novel diagnostics and vaccines. In the present study, we identified 646 T. canis proteins from TES and larval extract using 1D-SDS PAGE followed by mass spectrometry. A wide range of proteins was identified that may play a role both in the induction of the host immune response and host pathology, and in parasite metabolism and survival. Among these proteins there are potential candidates for novel diagnostics and vaccines for dogs and cats toxocariases.
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Full text: 1 Database: MEDLINE Main subject: Helminth Proteins / Toxocara canis / Proteomics / Larva Limits: Animals / Female / Humans Language: En Year: 2018 Type: Article
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Full text: 1 Database: MEDLINE Main subject: Helminth Proteins / Toxocara canis / Proteomics / Larva Limits: Animals / Female / Humans Language: En Year: 2018 Type: Article