(2R,3R)Dihydromyricetin inhibits osteoclastogenesis and bone loss through scavenging LPS-induced oxidative stress and NF-&#954;B and MAPKs pathways activating.

Zhang, Xuejun; Li, Xin; Fang, Jianguo; Hou, Xiaolong; Fang, Huang; Guo, Fengjing; Li, Feng; Chen, Anmin; Huang, Shilong

(2R,3R)Dihydromyricetin inhibits osteoclastogenesis and bone loss through scavenging LPS-induced oxidative stress and NF-κB and MAPKs pathways activating.

Zhang, Xuejun; Li, Xin; Fang, Jianguo; Hou, Xiaolong; Fang, Huang; Guo, Fengjing; Li, Feng; Chen, Anmin; Huang, Shilong.

Affiliation

Zhang X; Department of Orthopedics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Li X; Department of Pediatrics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Fang J; Department of Pharmacy, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Hou X; Department of Pharmacy, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Fang H; Department of Orthopedics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Guo F; Department of Orthopedics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Li F; Department of Orthopedics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Chen A; Department of Orthopedics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Huang S; Department of Orthopedics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

J Cell Biochem ; 119(11): 8981-8995, 2018 11.

Article in En | MEDLINE | ID: mdl-30076654

Subject(s)

Bone Resorption/drug therapy; Flavonols/pharmacology; Mitogen-Activated Protein Kinases/metabolism; NF-kappa B/metabolism; Osteogenesis/drug effects; Animals; Lipopolysaccharides/pharmacology; Male; Mice; Nitric Oxide/metabolism; Nitric Oxide Synthase Type II/metabolism; Oxidative Stress/drug effects; RAW 264.7 Cells; Reactive Oxygen Species/metabolism; Signal Transduction/drug effects; Superoxide Dismutase/metabolism

Key words

dihydromyricetin; nuclear factor κB; osteoclast; osteolysis; oxidative stress

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Full text: 1 Database: MEDLINE Main subject: Osteogenesis / Bone Resorption / NF-kappa B / Mitogen-Activated Protein Kinases / Flavonols Type of study: Prognostic_studies Limits: Animals Language: En Year: 2018 Type: Article

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