Association of Serum SorLA with Intimal Hyperplasia after Carotid Endarterectomy Operation: A Retrospective Analysis.

ABSTRACT

BACKGROUND: To study the relevance between serum sorting protein-related receptor containing the low-density lipoprotein receptor class A (SorLA) and intimal hyperplasia (IH) after carotid endarterectomy (CEA) operation. METHODS: Seventy-nine carotid artery stenosis patients receiving CEA operation from September 2013 to March 2015 were included. Serum SorLA level was detected by enzyme linked immunosorbent assay method preoperatively. All the 79 patients received regular follow-up to diagnose the IH of target lesions, postoperatively. Based on the follow-up data, the patients were divided into IH group (n = 10) and non-IH group (n = 69). Serum SorLA levels were analyzed using t-test. Receiver-operating characteristic curve was applied to determine the value of serum SorLA to predict the occurrence of IH after CEA operation. RESULTS: Patients in severe IH group had a higher level of serum SorLA than patients in non-IH group (1.648 ± 0.246 ng/mL vs. 1.278 ± 0.281 ng/mL, P < 0.001). When 1.44 ng/mL was designated as the cutoff value of serum SorLA, the predicting value had a sensitivity of 90% and a specificity of 73.5%. CONCLUSIONS: High serum SorLA level is related to IH after CEA operation. A serum SorLA level of 1.44 ng/mL can be used as a predicting index of postoperative IH.