CTCF is required for maintenance of auditory hair cells and hearing function in the mouse cochlea.

Ma, Ji-Hyun; Kim, Hyoung-Pyo; Bok, Jinwoong; Shin, Jeong-Oh

Ma, Ji-Hyun; Kim, Hyoung-Pyo; Bok, Jinwoong; Shin, Jeong-Oh.

Affiliation

Ma JH; Department of Anatomy, Republic of Korea.
Kim HP; Department of Environmental Medical Biology, Republic of Korea; BK21 PLUS Project for Medical Science, Republic of Korea.
Bok J; Department of Anatomy, Republic of Korea; BK21 PLUS Project for Medical Science, Republic of Korea; Department of Otorhinolaryngology, Yonsei University College of Medicine, Seoul, 03722, Republic of Korea.
Shin JO; Department of Anatomy, Republic of Korea. Electronic address: sjo98@yuhs.ac.

Biochem Biophys Res Commun ; 503(4): 2646-2652, 2018 09 18.

Article in En | MEDLINE | ID: mdl-30107916

Subject(s)

CCCTC-Binding Factor/genetics; Epigenesis, Genetic; Hair Cells, Auditory/metabolism; Hearing/physiology; Spiral Ganglion/metabolism; Animals; Basic Helix-Loop-Helix Transcription Factors/genetics; Basic Helix-Loop-Helix Transcription Factors/metabolism; CCCTC-Binding Factor/deficiency; Cell Differentiation; Cell Movement; Female; Gene Expression Regulation, Developmental; Hair Cells, Auditory/pathology; Integrases/genetics; Integrases/metabolism; Male; Mice; Mice, Knockout; Neurogenesis/genetics; SOXB1 Transcription Factors/genetics; SOXB1 Transcription Factors/metabolism; Spiral Ganglion/pathology; Stereocilia/metabolism; Stereocilia/pathology

Key words

CCCTC-Binding factor (CTCF); Hair cell; Hearing loss

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Full text: 1 Database: MEDLINE Main subject: Spiral Ganglion / Epigenesis, Genetic / CCCTC-Binding Factor / Hair Cells, Auditory / Hearing Limits: Animals Language: En Year: 2018 Type: Article

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