Rab6 promotes insulin receptor and cathepsin trafficking to regulate autophagy induction and activity in <i>Drosophila</i>.

Ayala, Carlos I; Kim, Jung; Neufeld, Thomas P

Rab6 promotes insulin receptor and cathepsin trafficking to regulate autophagy induction and activity in Drosophila.

Ayala, Carlos I; Kim, Jung; Neufeld, Thomas P.

Affiliation

Ayala CI; Department of Genetics, Cell Biology and Development, 6-160 Jackson Hall, 321 Church St. SE, University of Minnesota, Minneapolis, MN 55455, USA.
Kim J; Department of Molecular and Cell Biology, University of California at Berkeley, Berkeley, CA 94720, USA.
Neufeld TP; Department of Genetics, Cell Biology and Development, 6-160 Jackson Hall, 321 Church St. SE, University of Minnesota, Minneapolis, MN 55455, USA neufe003@umn.edu.

J Cell Sci ; 131(17)2018 09 07.

Article in En | MEDLINE | ID: mdl-30111579

Subject(s)

Autophagy; Cathepsin D/metabolism; Drosophila Proteins/metabolism; Drosophila/metabolism; Receptor Protein-Tyrosine Kinases/metabolism; rab GTP-Binding Proteins/metabolism; Animals; Cathepsin D/genetics; Cell Membrane/genetics; Cell Membrane/metabolism; Drosophila/cytology; Drosophila/genetics; Drosophila Proteins/genetics; Lysosomes/genetics; Lysosomes/metabolism; Protein Transport; Receptor Protein-Tyrosine Kinases/genetics; Signal Transduction; rab GTP-Binding Proteins/genetics

Key words

Autophagy; Cathepsin; Drosophila; Insulin; Rab6; Target of rapamycin; Vesicular trafficking

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Full text: 1 Database: MEDLINE Main subject: Autophagy / Cathepsin D / Receptor Protein-Tyrosine Kinases / Rab GTP-Binding Proteins / Drosophila Proteins / Drosophila Type of study: Prognostic_studies Limits: Animals Language: En Year: 2018 Type: Article

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