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Identification of canine cytochrome P-450s (CYPs) metabolizing the tramadol (+)-M1 and (+)-M2 metabolites to the tramadol (+)-M5 metabolite in dog liver microsomes.
Perez Jimenez, Tania E; Mealey, Katrina L; Schnider, Darren; Grubb, Tamara L; Greene, Stephen A; Court, Michael H.
Affiliation
  • Perez Jimenez TE; Program in Individualized Medicine (PrIMe), Department of Veterinary Clinical Sciences, Pharmacogenomics Laboratory, Washington State University College of Veterinary Medicine, Pullman, Washington.
  • Mealey KL; Program in Individualized Medicine (PrIMe), Department of Veterinary Clinical Sciences, Pharmacogenomics Laboratory, Washington State University College of Veterinary Medicine, Pullman, Washington.
  • Schnider D; Program in Individualized Medicine (PrIMe), Department of Veterinary Clinical Sciences, Pharmacogenomics Laboratory, Washington State University College of Veterinary Medicine, Pullman, Washington.
  • Grubb TL; Program in Individualized Medicine (PrIMe), Department of Veterinary Clinical Sciences, Pharmacogenomics Laboratory, Washington State University College of Veterinary Medicine, Pullman, Washington.
  • Greene SA; Program in Individualized Medicine (PrIMe), Department of Veterinary Clinical Sciences, Pharmacogenomics Laboratory, Washington State University College of Veterinary Medicine, Pullman, Washington.
  • Court MH; Program in Individualized Medicine (PrIMe), Department of Veterinary Clinical Sciences, Pharmacogenomics Laboratory, Washington State University College of Veterinary Medicine, Pullman, Washington.
J Vet Pharmacol Ther ; 41(6): 815-824, 2018 Dec.
Article in En | MEDLINE | ID: mdl-30113702
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Full text: 1 Database: MEDLINE Main subject: Steroid Hydroxylases / Tramadol / Microsomes, Liver / Aryl Hydrocarbon Hydroxylases / Dogs / Cytochrome P450 Family 2 / Analgesics, Opioid Type of study: Diagnostic_studies Limits: Animals / Female / Humans / Male Language: En Year: 2018 Type: Article
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Full text: 1 Database: MEDLINE Main subject: Steroid Hydroxylases / Tramadol / Microsomes, Liver / Aryl Hydrocarbon Hydroxylases / Dogs / Cytochrome P450 Family 2 / Analgesics, Opioid Type of study: Diagnostic_studies Limits: Animals / Female / Humans / Male Language: En Year: 2018 Type: Article