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Applications of Immunopharmacogenomics: Predicting, Preventing, and Understanding Immune-Mediated Adverse Drug Reactions.
Karnes, Jason H; Miller, Matthew A; White, Katie D; Konvinse, Katherine C; Pavlos, Rebecca K; Redwood, Alec J; Peter, Jonathan G; Lehloenya, Rannakoe; Mallal, Simon A; Phillips, Elizabeth J.
Affiliation
  • Karnes JH; Department of Pharmacy Practice and Science, University of Arizona College of Pharmacy, Tucson, Arizona 85721, USA.
  • Miller MA; Sarver Heart Center, University of Arizona College of Medicine, Tucson, Arizona 85724, USA.
  • White KD; Division of Pharmacogenomics, Center for Applied Genetics and Genomic Medicine (TCAG2M), Tucson, Arizona 85721, USA.
  • Konvinse KC; Department of Pharmacy Practice and Science, University of Arizona College of Pharmacy, Tucson, Arizona 85721, USA.
  • Pavlos RK; Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA; email: elizabeth.j.phillips@vanderbilt.edu.
  • Redwood AJ; Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA.
  • Peter JG; Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA.
  • Lehloenya R; Wesfarmers Centre of Vaccines and Infectious Diseases, Telethon Kids Institute, Subiaco, Western Australia 6008, Australia.
  • Mallal SA; Institute for Immunology and Infectious Diseases, Murdoch University, Perth, Western Australia 6150, Australia.
  • Phillips EJ; Institute for Immunology and Infectious Diseases, Murdoch University, Perth, Western Australia 6150, Australia.
Annu Rev Pharmacol Toxicol ; 59: 463-486, 2019 01 06.
Article in En | MEDLINE | ID: mdl-30134124
ABSTRACT
Adverse drug reactions (ADRs) are a significant health care burden. Immune-mediated adverse drug reactions (IM-ADRs) are responsible for one-fifth of ADRs but contribute a disproportionately high amount of that burden due to their severity. Variation in human leukocyte antigen ( HLA) genes has emerged as a potential preprescription screening strategy for the prevention of previously unpredictable IM-ADRs. Immunopharmacogenomics combines the disciplines of immunogenomics and pharmacogenomics and focuses on the effects of immune-specific variation on drug disposition and IM-ADRs. In this review, we present the latest evidence for HLA associations with IM-ADRs, ongoing research into biological mechanisms of IM-ADRs, and the translation of clinical actionable biomarkers for IM-ADRs, with a focus on T cell-mediated ADRs.
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Full text: 1 Database: MEDLINE Main subject: Drug-Related Side Effects and Adverse Reactions Type of study: Prognostic_studies / Risk_factors_studies Limits: Humans Language: En Year: 2019 Type: Article
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PubMed Links
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Full text: 1 Database: MEDLINE Main subject: Drug-Related Side Effects and Adverse Reactions Type of study: Prognostic_studies / Risk_factors_studies Limits: Humans Language: En Year: 2019 Type: Article