Adjunctive Clavulanic Acid Abolishes the Cefazolin Inoculum Effect in an Experimental Rat Model of Methicillin-Sensitive Staphylococcus aureus Endocarditis.
Antimicrob Agents Chemother
; 62(11)2018 11.
Article
in En
| MEDLINE
| ID: mdl-30150459
ABSTRACT
We tested the ability of clavulanic acid to restore the efficacy of cefazolin against Staphylococcus aureus TX0117, which exhibits the cefazolin inoculum effect (CzIE). In the rat infective endocarditis model, the coadministration of cefazolin plus clavulanic acid resulted in a significant reduction of bacterial counts (7.1 ± 0.5 log10 CFU/g) compared to that with cefazolin alone (2 ± 0.6 log10 CFU/g; P < 0.0001). The addition of a ß-lactamase inhibitor may be a viable strategy for overcoming the CzIE.
Key words
Full text:
1
Database:
MEDLINE
Main subject:
Staphylococcal Infections
/
Staphylococcus aureus
/
Cefazolin
/
Clavulanic Acid
/
Endocarditis
/
Endocarditis, Bacterial
/
Methicillin
Type of study:
Diagnostic_studies
Limits:
Animals
Language:
En
Year:
2018
Type:
Article