Increasing Trends in Transplantation of HCV-Positive Livers Into Uninfected Recipients.
Clin Gastroenterol Hepatol
; 17(8): 1634-1636, 2019 07.
Article
in En
| MEDLINE
| ID: mdl-30268562
ABSTRACT
The introduction of direct-acting antiviral (DAA) agents and the opioid epidemic have resulted in an increased interest in liver transplantation (LT) of organs from donors with hepatitis C virus (HCV)-related viremia.1 In March of 2015, the Organ Procurement and Transplantation Network/United Network for Organ Sharing (OPTN/UNOS) implemented a policy to perform HCV nucleic acid testing (NAT) in all HCV-seropositive donors. An open-label, single-center experience with 10 patients using a multistep informed consent reported successful transplantation of HCV-seropositive viremic (HCV-V) kidneys into HCV-seronegative recipients.2 Subsequently, a case was reported in which an HCV-V liver was transplanted into a HCV-seronegative recipient.3 In collaboration with OPTN/UNOS, we identified cases in which HCV-V deceased donor livers were transplanted into HCV-seronegative recipients.
Full text:
1
Database:
MEDLINE
Main subject:
Tissue and Organ Procurement
/
DNA, Viral
/
Liver Transplantation
/
Hepacivirus
/
Hepatitis C Antibodies
/
Transplant Recipients
/
Liver
Type of study:
Observational_studies
/
Prognostic_studies
Limits:
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Country/Region as subject:
America do norte
Language:
En
Year:
2019
Type:
Article