Influence of circadian rhythm on exhaled breath profiling by electronic nose.
J Biol Regul Homeost Agents
; 32(5): 1261-1265, 2018.
Article
in En
| MEDLINE
| ID: mdl-30334423
ABSTRACT
Electronic noses (e-noses) are a cheap and easy method for exhaled Volatile Organic Compound (VOC)-analysis which has shown its potential in several diseases. Before obtaining a full validation of these instruments in clinical settings, a number of methodological issues still have to be established. We aimed to investigate a potential influence of circadian variation on VOC-profile analyzed by an e-nose in healthy subjects. We enrolled 22 adults free of any known diseases. A sequence of exhaled breath samplings were performed on all participants at predetermined hours (7am, 12pm, 17pm, 23pm) and analyzed by an e-nose (Cyranose 320). According to Principal Component Analysis, significant circadian variations of the exhaled VOC-profile were shown for Principal Component (PC) 1 and 3. In detail, PC1 and PC3 values were significantly higher in the morning compared to the afternoon and evening (for all parameters p less than 0.05). Successive Linear Discriminant analysis confirmed the findings above. The daily variations in VOCs-profile, with the peak in the morning, could be relevant for future clinical applications, especially in the choice of optimal time for sampling patients.
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Database:
MEDLINE
Main subject:
Breath Tests
/
Circadian Rhythm
/
Exhalation
/
Electronic Nose
Type of study:
Prognostic_studies
Limits:
Adult
/
Humans
Language:
En
Year:
2018
Type:
Article