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Increasing FIM2/3 antigen-content improves efficacy of Bordetella pertussis vaccines in mice in vivo without altering vaccine-induced human reactogenicity biomarkers in vitro.
Queenan, Anne Marie; Dowling, David J; Cheng, Wing Ki; Faé, Kellen; Fernandez, Jeffrey; Flynn, Peter J; Joshi, Sweta; Brightman, Spencer E; Ramirez, Juan; Serroyen, Jan; Wiertsema, Selma; Fortanier, Alexandre; van den Dobbelsteen, Germie; Levy, Ofer; Poolman, Jan.
Affiliation
  • Queenan AM; Janssen Research & Development, Raritan, NJ 08869, USA.
  • Dowling DJ; Precision Vaccines Program, Division of Infectious Diseases, Boston Children's Hospital, Boston, MA, USA; Harvard Medical School, Boston, MA, USA.
  • Cheng WK; Precision Vaccines Program, Division of Infectious Diseases, Boston Children's Hospital, Boston, MA, USA; Harvard Medical School, Boston, MA, USA.
  • Faé K; Janssen Vaccines and Prevention, Leiden 2333CN, the Netherlands.
  • Fernandez J; Janssen Research & Development, Spring House, PA 19477, USA.
  • Flynn PJ; Precision Vaccines Program, Division of Infectious Diseases, Boston Children's Hospital, Boston, MA, USA.
  • Joshi S; Precision Vaccines Program, Division of Infectious Diseases, Boston Children's Hospital, Boston, MA, USA.
  • Brightman SE; Precision Vaccines Program, Division of Infectious Diseases, Boston Children's Hospital, Boston, MA, USA.
  • Ramirez J; Precision Vaccines Program, Division of Infectious Diseases, Boston Children's Hospital, Boston, MA, USA.
  • Serroyen J; Janssen Vaccines and Prevention, Leiden 2333CN, the Netherlands.
  • Wiertsema S; Janssen Vaccines and Prevention, Leiden 2333CN, the Netherlands.
  • Fortanier A; Janssen Vaccines and Prevention, Leiden 2333CN, the Netherlands.
  • van den Dobbelsteen G; Janssen Vaccines and Prevention, Leiden 2333CN, the Netherlands.
  • Levy O; Precision Vaccines Program, Division of Infectious Diseases, Boston Children's Hospital, Boston, MA, USA; Harvard Medical School, Boston, MA, USA; Broad Institute of MIT & Harvard, USA. Electronic address: ofer.levy@childrens.harvard.edu.
  • Poolman J; Janssen Vaccines and Prevention, Leiden 2333CN, the Netherlands.
Vaccine ; 37(1): 80-89, 2019 01 03.
Article in En | MEDLINE | ID: mdl-30478007
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Full text: 1 Database: MEDLINE Main subject: Virulence Factors, Bordetella / Pertussis Vaccine / Whooping Cough / Fimbriae Proteins / Antigens, Bacterial Type of study: Prognostic_studies / Risk_factors_studies Limits: Animals / Female / Humans Language: En Year: 2019 Type: Article
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Full text: 1 Database: MEDLINE Main subject: Virulence Factors, Bordetella / Pertussis Vaccine / Whooping Cough / Fimbriae Proteins / Antigens, Bacterial Type of study: Prognostic_studies / Risk_factors_studies Limits: Animals / Female / Humans Language: En Year: 2019 Type: Article