Defective collagen binding and increased bleeding in a murine model of von Willebrand disease affecting collagen IV binding.

Slobodianuk, T L; Kochelek, C; Foeckler, J; Kalloway, S; Weiler, H; Flood, V H

Defective collagen binding and increased bleeding in a murine model of von Willebrand disease affecting collagen IV binding.

Slobodianuk, T L; Kochelek, C; Foeckler, J; Kalloway, S; Weiler, H; Flood, V H.

Affiliation

Slobodianuk TL; Blood Research Institute, BloodCenter of Wisconsin, Milwaukee, WI, USA.
Kochelek C; Children's Research Institute, Children's Hospital of Wisconsin, Milwaukee, WI, USA.
Foeckler J; Blood Research Institute, BloodCenter of Wisconsin, Milwaukee, WI, USA.
Kalloway S; Children's Research Institute, Children's Hospital of Wisconsin, Milwaukee, WI, USA.
Weiler H; Transgenic Core, Medical College of Wisconsin, Milwaukee, WI, USA.
Flood VH; Transgenic Core, Medical College of Wisconsin, Milwaukee, WI, USA.

J Thromb Haemost ; 17(1): 63-71, 2019 01.

Article in En | MEDLINE | ID: mdl-30565388

Subject(s)

Collagen Type IV/metabolism; Hemorrhage/blood; Hemostasis; Platelet Adhesiveness; von Willebrand Diseases/blood; von Willebrand Factor/metabolism; Animals; Disease Models, Animal; Hemorrhage/genetics; Homozygote; Mice, Inbred C57BL; Mice, Transgenic; Mutation; Platelet Aggregation; Protein Binding; Protein Interaction Domains and Motifs; von Willebrand Diseases/genetics; von Willebrand Factor/genetics

Key words

bleeding; collagen; thrombosis; von Willebrand disease; von Willebrand factor

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Full text: 1 Database: MEDLINE Main subject: Von Willebrand Diseases / Von Willebrand Factor / Platelet Adhesiveness / Collagen Type IV / Hemorrhage / Hemostasis Type of study: Prognostic_studies Limits: Animals Language: En Year: 2019 Type: Article

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