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Evolution of Cancer Progression in the Context of Darwinism.
Lacina, Lukás; Coma, Matús; Dvoránková, Barbora; Kodet, Ondrej; Melegová, Nikola; Gál, Peter; Smetana, Karel.
Affiliation
  • Lacina L; Institute of Anatomy, First Faculty of Medicine, Charles University, Prague, Czech Republic.
  • Coma M; Department of Dermatology and Venereology, First Faculty of Medicine and General University Hospital, Charles University, Prague, Czech Republic.
  • Dvoránková B; BIOCEV, First Faculty of Medicine, Charles University, Vestec, Czech Republic.
  • Kodet O; Department of Pharmacology, Faculty of Medicine, Kosice, Slovak Republic.
  • Melegová N; Department of Biomedical Research, East-Slovak Institute of Cardiovascular Diseases, Inc., Kosice, Slovak Republic.
  • Gál P; Institute of Anatomy, First Faculty of Medicine, Charles University, Prague, Czech Republic.
  • Smetana K; Department of Dermatology and Venereology, First Faculty of Medicine and General University Hospital, Charles University, Prague, Czech Republic.
Anticancer Res ; 39(1): 1-16, 2019 Jan.
Article in En | MEDLINE | ID: mdl-30591435
ABSTRACT
Our review compares evolution of cancer in the human body to the origin of new species from a common ancestor organism with respect to the theory of Charles Darwin. Moreover, the functional role of the tumor microenvironment as a selective pressure actively participating in cancer progression is also demonstrated. Evolutionary aspects of tumor growth and invasion from the point of view of modern therapeutic challenges and opportunities in precision personalized medicine are also discussed.
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Full text: 1 Database: MEDLINE Main subject: Selection, Genetic / Biological Evolution / Precision Medicine / Neoplasms Limits: Humans Language: En Year: 2019 Type: Article
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Full text: 1 Database: MEDLINE Main subject: Selection, Genetic / Biological Evolution / Precision Medicine / Neoplasms Limits: Humans Language: En Year: 2019 Type: Article