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Convergences of Life Sciences and Engineering in Understanding and Treating Heart Failure.
Berry, Joel L; Zhu, Wuqiang; Tang, Yao Liang; Krishnamurthy, Prasanna; Ge, Ying; Cooke, John P; Chen, Yabing; Garry, Daniel J; Yang, Huang-Tian; Rajasekaran, Namakkal Soorapan; Koch, Walter J; Li, Song; Domae, Keitaro; Qin, Gangjian; Cheng, Ke; Kamp, Timothy J; Ye, Lei; Hu, Shijun; Ogle, Brenda M; Rogers, Jack M; Abel, E Dale; Davis, Michael E; Prabhu, Sumanth D; Liao, Ronglih; Pu, William T; Wang, Yibin; Ping, Peipei; Bursac, Nenad; Vunjak-Novakovic, Gordana; Wu, Joseph C; Bolli, Roberto; Menasché, Philippe; Zhang, Jianyi.
Affiliation
  • Berry JL; From the Department of Biomedical Engineering (J.L.B., W.Z., P.K., G.Q., J.M.R., J.Z.), University of Alabama at Birmingham.
  • Zhu W; From the Department of Biomedical Engineering (J.L.B., W.Z., P.K., G.Q., J.M.R., J.Z.), University of Alabama at Birmingham.
  • Tang YL; Vascular Biology Center, Medical College of Georgia, Augusta University (Y.T.).
  • Krishnamurthy P; From the Department of Biomedical Engineering (J.L.B., W.Z., P.K., G.Q., J.M.R., J.Z.), University of Alabama at Birmingham.
  • Ge Y; Department of Cell and Regenerative Biology, University of Wisconsin-Madison, (Y.G., T.J.K.).
  • Cooke JP; Department of Cardiovascular Sciences, Houston Methodist Research Institute, TX (J.P.C.).
  • Chen Y; Department of Pathology (Y.C., N.S.R.), University of Alabama at Birmingham.
  • Garry DJ; Lillehei Heart Institute, Department of Medicine, Division of Cardiology, University of Minnesota, Minneapolis (D.J.G.).
  • Yang HT; Shanghai Institutes for Biological Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences (CAS), China (H.-T.Y.).
  • Rajasekaran NS; Department of Pathology (Y.C., N.S.R.), University of Alabama at Birmingham.
  • Koch WJ; Department of Pharmacology, Center for Translational Medicine, Lewis Katz School of Medicine, Temple University, Philadelphia, PA (W.J.K.).
  • Li S; Department of Bioengineering, University of California at Los Angeles (S.L.).
  • Domae K; Department of Cardiovascular Surgery, Graduate School of Medicine, Osaka University, Japan (K.D.).
  • Qin G; From the Department of Biomedical Engineering (J.L.B., W.Z., P.K., G.Q., J.M.R., J.Z.), University of Alabama at Birmingham.
  • Cheng K; Department of Molecular Biomedical Sciences, North Carolina State University, Raleigh (K.C.).
  • Kamp TJ; Department of Cell and Regenerative Biology, University of Wisconsin-Madison, (Y.G., T.J.K.).
  • Ye L; National Heart Research Institute Singapore, National Heart Centre Singapore (L.Y.).
  • Hu S; Institute for Cardiovascular Science, Medical College of Soochow University, Suzhou, China (S.H.).
  • Ogle BM; Department of Biomedical Engineering, University of Minnesota-Twin Cities, Minneapolis, MN (B.M.O.).
  • Rogers JM; From the Department of Biomedical Engineering (J.L.B., W.Z., P.K., G.Q., J.M.R., J.Z.), University of Alabama at Birmingham.
  • Abel ED; Division of Endocrinology and Metabolism, Department of Internal Medicine, Fraternal Order of Eagles Diabetes Research Center, University of Iowa Carver College of Medicine (E.D.A.).
  • Davis ME; Wallace H. Coulter Department of Biomedical Engineering, Georgia Tech College of Engineering and Emory University School of Medicine, Atlanta (M.E.D.).
  • Prabhu SD; Division of Cardiovascular Disease and Comprehensive Cardiovascular Center, Department of Medicine (S.D.P.), University of Alabama at Birmingham.
  • Liao R; Stanford Cardiovascular Institute, Department of Medicine, Stanford University School of Medicine, CA (R.L., J.C.W.).
  • Pu WT; Department of Cardiology, Boston Children's Hospital, MA (W.T.P.).
  • Wang Y; Department of Anesthesiology and Medicine (Y.W.), David Geffen School of Medicine, University of California, Los Angeles.
  • Ping P; Department of Physiology (P.P.), David Geffen School of Medicine, University of California, Los Angeles.
  • Bursac N; Department of Biomedical Engineering, Duke University, Durham, NC (N.B.).
  • Vunjak-Novakovic G; Department of Biomedical Engineering and Department of Medicine, Columbia University, New York City, NY (G.V.-N.).
  • Wu JC; Stanford Cardiovascular Institute, Department of Medicine, Stanford University School of Medicine, CA (R.L., J.C.W.).
  • Bolli R; Institute of Molecular Cardiology, Department of Medicine, University of Louisville, KY (R.B.).
  • Menasché P; Department of Cardiovascular Surgery, Hôpital Européen Georges Pompidou, Paris, France (P.M.).
  • Zhang J; From the Department of Biomedical Engineering (J.L.B., W.Z., P.K., G.Q., J.M.R., J.Z.), University of Alabama at Birmingham.
Circ Res ; 124(1): 161-169, 2019 01 04.
Article in En | MEDLINE | ID: mdl-30605412
ABSTRACT
On March 1 and 2, 2018, the National Institutes of Health 2018 Progenitor Cell Translational Consortium, Cardiovascular Bioengineering Symposium, was held at the University of Alabama at Birmingham. Convergence of life sciences and engineering to advance the understanding and treatment of heart failure was the theme of the meeting. Over 150 attendees were present, and >40 scientists presented their latest work on engineering human functional myocardium for disease modeling, drug development, and heart failure research. The scientists, engineers, and physicians in the field of cardiovascular sciences met and discussed the most recent advances in their work and proposed future strategies for overcoming the major roadblocks of cardiovascular bioengineering and therapy. Particular emphasis was given for manipulation and using of stem/progenitor cells, biomaterials, and methods to provide molecular, chemical, and mechanical cues to cells to influence their identity and fate in vitro and in vivo. Collectively, these works are profoundly impacting and progressing toward deciphering the mechanisms and developing novel treatments for left ventricular dysfunction of failing hearts. Here, we present some important perspectives that emerged from this meeting.
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Full text: 1 Database: MEDLINE Main subject: Biomedical Engineering / Biological Science Disciplines / Interdisciplinary Communication / Biomedical Research / Heart Failure Type of study: Sysrev_observational_studies Limits: Animals / Humans Language: En Year: 2019 Type: Article
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Full text: 1 Database: MEDLINE Main subject: Biomedical Engineering / Biological Science Disciplines / Interdisciplinary Communication / Biomedical Research / Heart Failure Type of study: Sysrev_observational_studies Limits: Animals / Humans Language: En Year: 2019 Type: Article