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CNS-derived extracellular vesicles from superoxide dismutase 1 (SOD1)G93A ALS mice originate from astrocytes and neurons and carry misfolded SOD1.
Silverman, Judith M; Christy, Darren; Shyu, Chih Cheih; Moon, Kyung-Mee; Fernando, Sarah; Gidden, Zoe; Cowan, Catherine M; Ban, Yuxin; Stacey, R Greg; Grad, Leslie I; McAlary, Luke; Mackenzie, Ian R; Foster, Leonard J; Cashman, Neil R.
Affiliation
  • Silverman JM; From the Centre for Brain Health, Department of Medicine, University of British Columbia, Vancouver, British Columbia V6T 1B5, Canada.
  • Christy D; From the Centre for Brain Health, Department of Medicine, University of British Columbia, Vancouver, British Columbia V6T 1B5, Canada.
  • Shyu CC; From the Centre for Brain Health, Department of Medicine, University of British Columbia, Vancouver, British Columbia V6T 1B5, Canada.
  • Moon KM; the Centre for High-throughput Biology, University of British Columbia, Vancouver, British Columbia V6T 1B5, Canada.
  • Fernando S; From the Centre for Brain Health, Department of Medicine, University of British Columbia, Vancouver, British Columbia V6T 1B5, Canada.
  • Gidden Z; From the Centre for Brain Health, Department of Medicine, University of British Columbia, Vancouver, British Columbia V6T 1B5, Canada.
  • Cowan CM; From the Centre for Brain Health, Department of Medicine, University of British Columbia, Vancouver, British Columbia V6T 1B5, Canada.
  • Ban Y; From the Centre for Brain Health, Department of Medicine, University of British Columbia, Vancouver, British Columbia V6T 1B5, Canada.
  • Stacey RG; the Centre for High-throughput Biology, University of British Columbia, Vancouver, British Columbia V6T 1B5, Canada.
  • Grad LI; From the Centre for Brain Health, Department of Medicine, University of British Columbia, Vancouver, British Columbia V6T 1B5, Canada.
  • McAlary L; From the Centre for Brain Health, Department of Medicine, University of British Columbia, Vancouver, British Columbia V6T 1B5, Canada.
  • Mackenzie IR; the Department of Physics and Astronomy, University of British Columbia, Vancouver, British Columbia V6T 1Z1, Canada, and.
  • Foster LJ; the Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia V6T 1B5, Canada.
  • Cashman NR; the Centre for High-throughput Biology, University of British Columbia, Vancouver, British Columbia V6T 1B5, Canada.
J Biol Chem ; 294(10): 3744-3759, 2019 03 08.
Article in En | MEDLINE | ID: mdl-30635404
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Full text: 1 Database: MEDLINE Main subject: Astrocytes / Protein Folding / Extracellular Vesicles / Superoxide Dismutase-1 / Amyotrophic Lateral Sclerosis / Neurons Limits: Animals / Humans Language: En Year: 2019 Type: Article
Fulltext
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Full text: 1 Database: MEDLINE Main subject: Astrocytes / Protein Folding / Extracellular Vesicles / Superoxide Dismutase-1 / Amyotrophic Lateral Sclerosis / Neurons Limits: Animals / Humans Language: En Year: 2019 Type: Article