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Novel PIKK inhibitor antibody-drug conjugates: Synthesis and anti-tumor activity.
Zhou, Dahui; Casavant, Jeffrey; Graziani, Edmund I; He, Haiyin; Janso, Jeffrey; Loganzo, Frank; Musto, Sylvia; Tumey, Nathan; O'Donnell, Christopher J; Dushin, Russell.
Affiliation
  • Zhou D; Oncology Medicinal Chemistry, Pfizer Worldwide Research and Development, 445 Eastern Point Road, Groton, CT 06340, United States. Electronic address: dahui.zhou@pfizer.com.
  • Casavant J; Oncology Medicinal Chemistry, Pfizer Worldwide Research and Development, 445 Eastern Point Road, Groton, CT 06340, United States.
  • Graziani EI; Oncology Medicinal Chemistry, Pfizer Worldwide Research and Development, 445 Eastern Point Road, Groton, CT 06340, United States.
  • He H; Oncology Medicinal Chemistry, Pfizer Worldwide Research and Development, 445 Eastern Point Road, Groton, CT 06340, United States.
  • Janso J; Oncology Medicinal Chemistry, Pfizer Worldwide Research and Development, 445 Eastern Point Road, Groton, CT 06340, United States.
  • Loganzo F; Oncology Research East, Pfizer Worldwide Research and Development, 401 North Middletown Road, Pearl River, NY 10965, United States.
  • Musto S; Oncology Research East, Pfizer Worldwide Research and Development, 401 North Middletown Road, Pearl River, NY 10965, United States.
  • Tumey N; Oncology Medicinal Chemistry, Pfizer Worldwide Research and Development, 445 Eastern Point Road, Groton, CT 06340, United States.
  • O'Donnell CJ; Oncology Medicinal Chemistry, Pfizer Worldwide Research and Development, 445 Eastern Point Road, Groton, CT 06340, United States.
  • Dushin R; Oncology Medicinal Chemistry, Pfizer Worldwide Research and Development, 445 Eastern Point Road, Groton, CT 06340, United States.
Bioorg Med Chem Lett ; 29(7): 943-947, 2019 04 01.
Article in En | MEDLINE | ID: mdl-30655215
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Full text: 1 Database: MEDLINE Main subject: Pyrroles / Immunoconjugates / Trastuzumab / Phosphoinositide-3 Kinase Inhibitors / Aminoquinolines / Antineoplastic Agents Limits: Humans Language: En Year: 2019 Type: Article
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Full text: 1 Database: MEDLINE Main subject: Pyrroles / Immunoconjugates / Trastuzumab / Phosphoinositide-3 Kinase Inhibitors / Aminoquinolines / Antineoplastic Agents Limits: Humans Language: En Year: 2019 Type: Article