Clinical and translational pharmacology of the cathepsin K inhibitor odanacatib studied for osteoporosis.

Stone, Julie A; McCrea, Jacqueline B; Witter, Rose; Zajic, Stefan; Stoch, S Aubrey

Stone, Julie A; McCrea, Jacqueline B; Witter, Rose; Zajic, Stefan; Stoch, S Aubrey.

Affiliation

Stone JA; Merck & Co., Inc., Kenilworth, NJ, USA.
McCrea JB; Merck & Co., Inc., Kenilworth, NJ, USA.
Witter R; Merck & Co., Inc., Kenilworth, NJ, USA.
Zajic S; Merck & Co., Inc., Kenilworth, NJ, USA.
Stoch SA; Merck & Co., Inc., Kenilworth, NJ, USA.

Br J Clin Pharmacol ; 85(6): 1072-1083, 2019 06.

Article in En | MEDLINE | ID: mdl-30663085

Subject(s)

Biphenyl Compounds/therapeutic use; Bone Density Conservation Agents/therapeutic use; Bone Remodeling/drug effects; Bone and Bones/drug effects; Cathepsin K/antagonists & inhibitors; Cysteine Proteinase Inhibitors/therapeutic use; Osteoporosis/drug therapy; Animals; Biphenyl Compounds/adverse effects; Biphenyl Compounds/pharmacokinetics; Bone Density Conservation Agents/adverse effects; Bone Density Conservation Agents/pharmacokinetics; Bone and Bones/enzymology; Bone and Bones/physiopathology; Cathepsin K/metabolism; Cysteine Proteinase Inhibitors/adverse effects; Cysteine Proteinase Inhibitors/pharmacokinetics; Female; Humans; Male; Osteoporosis/enzymology; Osteoporosis/pathology; Signal Transduction; Translational Research, Biomedical; Treatment Outcome

Key words

clinical trials statistics and study design; odanacatib; osteoporosis; pharmacodynamics; pharmacokinetics

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Full text: 1 Database: MEDLINE Main subject: Osteoporosis / Biphenyl Compounds / Bone and Bones / Cysteine Proteinase Inhibitors / Bone Remodeling / Bone Density Conservation Agents / Cathepsin K Type of study: Prognostic_studies Limits: Animals / Female / Humans / Male Language: En Year: 2019 Type: Article

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