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Efficacy of Tedizolid against Enterococci and Staphylococci, Including cfr+ Strains, in a Mouse Peritonitis Model.
Singh, Kavindra V; Arias, Cesar A; Murray, Barbara E.
Affiliation
  • Singh KV; Division of Infectious Diseases, Department of Internal Medicine, University of Texas Health Science Center at Houston, Houston, Texas, USA kavindra.singh@uth.tmc.edu.
  • Arias CA; UTHealth Center for Antimicrobial Resistance and Microbial Genomics (CARMiG), Houston, Texas, USA.
  • Murray BE; Division of Infectious Diseases, Department of Internal Medicine, University of Texas Health Science Center at Houston, Houston, Texas, USA.
Antimicrob Agents Chemother ; 63(4)2019 04.
Article in En | MEDLINE | ID: mdl-30670435
ABSTRACT
In a mouse peritonitis model, tedizolid was comparable to linezolid and daptomycin against an Enterococcus faecium strain (VANr, AMPr), an Enterococcus faecalis strain, and a methicillin-resistant Staphylococcus aureus (MRSA) strain with and without cfr Against a cfr(B)+E. faecium, tedizolid was inferior in vivo to linezolid and daptomycin, despite an ∼4-fold lower MIC.
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Full text: 1 Database: MEDLINE Main subject: Peritonitis / Staphylococcus / Tetrazoles / Gram-Positive Bacterial Infections / Enterococcus faecium / Enterococcus faecalis / Oxazolidinones / Anti-Bacterial Agents Limits: Animals Language: En Year: 2019 Type: Article
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Full text: 1 Database: MEDLINE Main subject: Peritonitis / Staphylococcus / Tetrazoles / Gram-Positive Bacterial Infections / Enterococcus faecium / Enterococcus faecalis / Oxazolidinones / Anti-Bacterial Agents Limits: Animals Language: En Year: 2019 Type: Article