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MAPK Pathway Suppression Unmasks Latent DNA Repair Defects and Confers a Chemical Synthetic Vulnerability in BRAF-, NRAS-, and NF1-Mutant Melanomas.
Maertens, Ophélia; Kuzmickas, Ryan; Manchester, Haley E; Emerson, Chloe E; Gavin, Alessandra G; Guild, Caroline J; Wong, Terence C; De Raedt, Thomas; Bowman-Colin, Christian; Hatchi, Elodie; Garraway, Levi A; Flaherty, Keith T; Pathania, Shailja; Elledge, Stephen J; Cichowski, Karen.
Affiliation
  • Maertens O; Genetics Division, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts.
  • Kuzmickas R; Harvard Medical School, Boston, Massachusetts.
  • Manchester HE; Ludwig Center at Harvard, Boston, Massachusetts.
  • Emerson CE; Genetics Division, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts.
  • Gavin AG; Harvard Medical School, Boston, Massachusetts.
  • Guild CJ; Genetics Division, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts.
  • Wong TC; Harvard Medical School, Boston, Massachusetts.
  • De Raedt T; Genetics Division, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts.
  • Bowman-Colin C; Harvard Medical School, Boston, Massachusetts.
  • Hatchi E; Genetics Division, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts.
  • Garraway LA; Harvard Medical School, Boston, Massachusetts.
  • Flaherty KT; Genetics Division, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts.
  • Pathania S; Harvard Medical School, Boston, Massachusetts.
  • Elledge SJ; Department of Medical Oncology, Center for Cancer Precision Medicine, Dana-Farber Cancer Institute, Boston, Massachusetts.
  • Cichowski K; Cancer Program, Broad Institute of MIT and Harvard, Cambridge, Massachusetts.
Cancer Discov ; 9(4): 526-545, 2019 04.
Article in En | MEDLINE | ID: mdl-30709805
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Full text: 1 Database: MEDLINE Main subject: Genes, ras / MAP Kinase Kinase Kinases / DNA Repair / Melanoma Type of study: Prognostic_studies Limits: Humans Language: En Year: 2019 Type: Article
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PubMed Links
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Full text: 1 Database: MEDLINE Main subject: Genes, ras / MAP Kinase Kinase Kinases / DNA Repair / Melanoma Type of study: Prognostic_studies Limits: Humans Language: En Year: 2019 Type: Article