Bioactive Diterpenoids from the Stems of Euphorbia royleana.
J Nat Prod
; 82(2): 183-193, 2019 02 22.
Article
in En
| MEDLINE
| ID: mdl-30730729
ABSTRACT
Two ingenane- (1 and 2), two ent-atisane- (3 and 4), two ent-kaurane- (5 and 6), two ent-abietane- (7 and 8), and one ent-isopimarane-type (9) diterpenoid and 12 known analogues have been isolated from the methanolic extract of the stems of Euphorbia royleana. Their structures, including absolute configurations, were determined by extensive spectroscopic methods and ECD data analysis. The nitric oxide inhibitory activities of those diterpenoids were examined biologically in lipopolysaccharide-stimulated BV-2 cells, with compounds 1, 2, 5-7, 10, and 12 having IC50 values lower than 40 µM. Molecular docking was used to investigated the possible mechanism of compounds 1, 2, 5-7, 10, and 12.
Full text:
1
Database:
MEDLINE
Main subject:
Euphorbia
/
Diterpenes
Language:
En
Year:
2019
Type:
Article