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Small molecule nicotinamide N-methyltransferase inhibitor activates senescent muscle stem cells and improves regenerative capacity of aged skeletal muscle.
Neelakantan, Harshini; Brightwell, Camille R; Graber, Ted G; Maroto, Rosario; Wang, Hua-Yu Leo; McHardy, Stanton F; Papaconstantinou, John; Fry, Christopher S; Watowich, Stanley J.
Affiliation
  • Neelakantan H; Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, TX 77550, USA.
  • Brightwell CR; Department of Cell Biology, Neuroscience and Anatomy, University of Texas Medical Branch, Galveston, TX, USA; Department of Nutrition and Metabolism, University of Texas Medical Branch, Galveston, TX, USA.
  • Graber TG; Division of Rehabilitation Sciences, University of Texas Medical Branch, Galveston, TX, USA.
  • Maroto R; Department of Nutrition and Metabolism, University of Texas Medical Branch, Galveston, TX, USA.
  • Wang HL; Department of Chemistry and Center for Innovative Drug Discovery, University of Texas at San Antonio, San Antonio, TX, USA.
  • McHardy SF; Department of Chemistry and Center for Innovative Drug Discovery, University of Texas at San Antonio, San Antonio, TX, USA.
  • Papaconstantinou J; Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, TX 77550, USA.
  • Fry CS; Department of Nutrition and Metabolism, University of Texas Medical Branch, Galveston, TX, USA; Shriners Hospitals for Children, Galveston, TX, USA.
  • Watowich SJ; Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, TX 77550, USA. Electronic address: watowich@xray.utmb.edu.
Biochem Pharmacol ; 163: 481-492, 2019 05.
Article in En | MEDLINE | ID: mdl-30753815
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Full text: 1 Database: MEDLINE Main subject: Aging / Muscle, Skeletal / Nicotinamide N-Methyltransferase / Muscle Contraction Limits: Animals Language: En Year: 2019 Type: Article
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PubMed Links
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Full text: 1 Database: MEDLINE Main subject: Aging / Muscle, Skeletal / Nicotinamide N-Methyltransferase / Muscle Contraction Limits: Animals Language: En Year: 2019 Type: Article