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Highly potent and selective aryl-1,2,3-triazolyl benzylpiperidine inhibitors toward butyrylcholinesterase in Alzheimer's disease.
de Andrade, Peterson; Mantoani, Susimaire P; Gonçalves Nunes, Paulo Sérgio; Magadán, Carlos Roca; Pérez, Concepción; Xavier, Danilo Jordão; Hojo, Elza Tiemi Sakamoto; Campillo, Nuria E; Martínez, Ana; Carvalho, Ivone.
Affiliation
  • de Andrade P; School of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo, Av. Café s/n, 14040-930 Ribeirão Preto, SP, Brazil.
  • Mantoani SP; School of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo, Av. Café s/n, 14040-930 Ribeirão Preto, SP, Brazil.
  • Gonçalves Nunes PS; School of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo, Av. Café s/n, 14040-930 Ribeirão Preto, SP, Brazil.
  • Magadán CR; Centro de Investigaciones Biologicas (CIB-CSIC), Ramiro de Maeztu 9, Madrid 28040, Spain.
  • Pérez C; Instituto de Química Médica (IQM-CSIC), Juan de la Cierva 3, Madrid 28006, Spain.
  • Xavier DJ; Department of Genetics, Ribeirão Preto Medical School, University of São Paulo, Av. Bandeirantes 3900, 14049-900 Ribeirão Preto, SP, Brazil.
  • Hojo ETS; Department of Biology, Faculty of Philosophy, Sciences and Letters at Ribeirão Preto, University of São Paulo, Avenida Bandeirantes 3900, 14040-900 Ribeirão Preto, SP, Brazil.
  • Campillo NE; Centro de Investigaciones Biologicas (CIB-CSIC), Ramiro de Maeztu 9, Madrid 28040, Spain.
  • Martínez A; Centro de Investigaciones Biologicas (CIB-CSIC), Ramiro de Maeztu 9, Madrid 28040, Spain.
  • Carvalho I; School of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo, Av. Café s/n, 14040-930 Ribeirão Preto, SP, Brazil. Electronic address: carronal@usp.br.
Bioorg Med Chem ; 27(6): 931-943, 2019 03 15.
Article in En | MEDLINE | ID: mdl-30765302
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Full text: 1 Database: MEDLINE Main subject: Piperidines / Butyrylcholinesterase / Cholinesterase Inhibitors Limits: Humans Language: En Year: 2019 Type: Article
Fulltext
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Full text: 1 Database: MEDLINE Main subject: Piperidines / Butyrylcholinesterase / Cholinesterase Inhibitors Limits: Humans Language: En Year: 2019 Type: Article