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Lomustine-temozolomide combination therapy versus standard temozolomide therapy in patients with newly diagnosed glioblastoma with methylated MGMT promoter (CeTeG/NOA-09): a randomised, open-label, phase 3 trial.
Herrlinger, Ulrich; Tzaridis, Theophilos; Mack, Frederic; Steinbach, Joachim Peter; Schlegel, Uwe; Sabel, Michael; Hau, Peter; Kortmann, Rolf-Dieter; Krex, Dietmar; Grauer, Oliver; Goldbrunner, Roland; Schnell, Oliver; Bähr, Oliver; Uhl, Martin; Seidel, Clemens; Tabatabai, Ghazaleh; Kowalski, Thomas; Ringel, Florian; Schmidt-Graf, Friederike; Suchorska, Bogdana; Brehmer, Stefanie; Weyerbrock, Astrid; Renovanz, Miriam; Bullinger, Lars; Galldiks, Norbert; Vajkoczy, Peter; Misch, Martin; Vatter, Hartmut; Stuplich, Moritz; Schäfer, Niklas; Kebir, Sied; Weller, Johannes; Schaub, Christina; Stummer, Walter; Tonn, Jörg-Christian; Simon, Matthias; Keil, Vera C; Nelles, Michael; Urbach, Horst; Coenen, Martin; Wick, Wolfgang; Weller, Michael; Fimmers, Rolf; Schmid, Matthias; Hattingen, Elke; Pietsch, Torsten; Coch, Christoph; Glas, Martin.
Affiliation
  • Herrlinger U; Division of Clinical Neurooncology, Department of Neurology and Centre of Integrated Oncology, University Hospital Bonn, Bonn, Germany. Electronic address: ulrich.herrlinger@ukbonn.de.
  • Tzaridis T; Division of Clinical Neurooncology, Department of Neurology and Centre of Integrated Oncology, University Hospital Bonn, Bonn, Germany.
  • Mack F; Division of Clinical Neurooncology, Department of Neurology and Centre of Integrated Oncology, University Hospital Bonn, Bonn, Germany.
  • Steinbach JP; Dr Senckenberg Institute of Neurooncology, University of Frankfurt, Frankfurt, Germany.
  • Schlegel U; Department of Neurology, University Hospital Knappschaftskrankenhaus, Ruhr-Universität Bochum, Bochum, Germany.
  • Sabel M; Department of Neurosurgery, University of Düsseldorf, Düsseldorf, Germany.
  • Hau P; Department of Neurology and Wilhelm Sander Neurooncology Unit, University Hospital Regensburg, Regensburg, Germany.
  • Kortmann RD; Department of Radiation Oncology, University of Leipzig, Leipzig, Germany.
  • Krex D; Department of Neurosurgery, University of Dresden, Dresden, Germany.
  • Grauer O; Department of Neurology, University of Münster, Münster, Germany.
  • Goldbrunner R; Department of Neurosurgery, University of Cologne, Cologne, Germany.
  • Schnell O; Department of Neurosurgery, Ludwig Maximillian University of Munich and German Cancer Consortium, Partner Site Munich, Munich, Germany; Department of Neurosurgery, University of Freiburg, Freiburg, Germany.
  • Bähr O; Dr Senckenberg Institute of Neurooncology, University of Frankfurt, Frankfurt, Germany.
  • Uhl M; Department of Neurology and Wilhelm Sander Neurooncology Unit, University Hospital Regensburg, Regensburg, Germany.
  • Seidel C; Department of Radiation Oncology, University of Leipzig, Leipzig, Germany.
  • Tabatabai G; Interdisciplinary Division of Neurooncology, University of Tübingen, Tübingen, Germany.
  • Kowalski T; Department of Neurology, University Hospital Knappschaftskrankenhaus, Ruhr-Universität Bochum, Bochum, Germany.
  • Ringel F; Department of Neurosurgery, Technical University of Munich, Munich, Germany; Department of Neurosurgery, University of Mainz, Mainz, Germany.
  • Schmidt-Graf F; Department of Neurology, Technical University of Munich, Munich, Germany.
  • Suchorska B; Department of Neurosurgery, Ludwig Maximillian University of Munich and German Cancer Consortium, Partner Site Munich, Munich, Germany.
  • Brehmer S; Department of Neurosurgery, University of Mannheim, Mannheim, Germany.
  • Weyerbrock A; Department of Neurosurgery, University of Freiburg, Freiburg, Germany.
  • Renovanz M; Department of Neurosurgery, University of Mainz, Mainz, Germany.
  • Bullinger L; Department of Internal Medicine, University of Ulm, Ulm, Germany.
  • Galldiks N; Department of Neurology, University of Cologne, Cologne, Germany; Institute of Neuroscience and Medicine (INM-3), Juelich, Germany.
  • Vajkoczy P; Department of Neurosurgery, Charité University of Berlin, Berlin, Germany.
  • Misch M; Department of Neurosurgery, Charité University of Berlin, Berlin, Germany.
  • Vatter H; Department of Neurosurgery, University Hospital Bonn, Bonn, Germany.
  • Stuplich M; Division of Clinical Neurooncology, Department of Neurology and Centre of Integrated Oncology, University Hospital Bonn, Bonn, Germany.
  • Schäfer N; Division of Clinical Neurooncology, Department of Neurology and Centre of Integrated Oncology, University Hospital Bonn, Bonn, Germany.
  • Kebir S; Division of Clinical Neurooncology, Department of Neurology and Centre of Integrated Oncology, University Hospital Bonn, Bonn, Germany.
  • Weller J; Division of Clinical Neurooncology, Department of Neurology and Centre of Integrated Oncology, University Hospital Bonn, Bonn, Germany.
  • Schaub C; Division of Clinical Neurooncology, Department of Neurology and Centre of Integrated Oncology, University Hospital Bonn, Bonn, Germany.
  • Stummer W; Department of Neurosurgery, University of Münster, Münster, Germany.
  • Tonn JC; Department of Neurosurgery, Ludwig Maximillian University of Munich and German Cancer Consortium, Partner Site Munich, Munich, Germany.
  • Simon M; Department of Neurosurgery, University Hospital Bonn, Bonn, Germany.
  • Keil VC; Department of Neuroradiology, University Hospital Bonn, Bonn, Germany.
  • Nelles M; Department of Neuroradiology, University Hospital Bonn, Bonn, Germany.
  • Urbach H; Department of Neuroradiology, University Hospital Bonn, Bonn, Germany; Department of Neuroradiology, University of Freiburg, Freiburg, Germany.
  • Coenen M; Study Centre Bonn, University Hospital Bonn, Bonn, Germany.
  • Wick W; Department of Neurology, University of Heidelberg and German Cancer Research Center, Heidelberg, Germany.
  • Weller M; Department of Neurology, University Hospital and University of Zurich, Zurich, Switzerland.
  • Fimmers R; Institute for Medical Biometry, Informatics and Epidemiology, University Hospital Bonn, Bonn, Germany.
  • Schmid M; Institute for Medical Biometry, Informatics and Epidemiology, University Hospital Bonn, Bonn, Germany.
  • Hattingen E; Department of Neuroradiology, University Hospital Bonn, Bonn, Germany.
  • Pietsch T; Institute of Neuropathology and DGNN Brain Tumor Reference Centre, University Hospital Bonn, Bonn, Germany.
  • Coch C; Study Centre Bonn, University Hospital Bonn, Bonn, Germany.
  • Glas M; Division of Clinical Neurooncology, Department of Neurology and Centre of Integrated Oncology, University Hospital Bonn, Bonn, Germany; Division of Clinical Neurooncology, Department of Neurology and West German Cancer Center, German Cancer Consortium, Partner Site Essen, University Hospital Essen,
Lancet ; 393(10172): 678-688, 2019 02 16.
Article in En | MEDLINE | ID: mdl-30782343
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Full text: 1 Database: MEDLINE Main subject: Combined Modality Therapy / Glioblastoma / Antineoplastic Agents, Alkylating / Temozolomide / Lomustine Type of study: Clinical_trials / Diagnostic_studies Limits: Adult / Aged / Female / Humans / Male / Middle aged Language: En Year: 2019 Type: Article
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Full text: 1 Database: MEDLINE Main subject: Combined Modality Therapy / Glioblastoma / Antineoplastic Agents, Alkylating / Temozolomide / Lomustine Type of study: Clinical_trials / Diagnostic_studies Limits: Adult / Aged / Female / Humans / Male / Middle aged Language: En Year: 2019 Type: Article