Kaposi's sarcoma-associated herpesvirus ORF57 protein protects viral transcripts from specific nuclear RNA decay pathways by preventing hMTR4 recruitment.

Ruiz, Julio C; Hunter, Olga V; Conrad, Nicholas K

Ruiz, Julio C; Hunter, Olga V; Conrad, Nicholas K.

Affiliation

Ruiz JC; Department of Microbiology, University of Texas Southwestern Medical Center, Dallas, Texas.
Hunter OV; Department of Microbiology, University of Texas Southwestern Medical Center, Dallas, Texas.
Conrad NK; Department of Microbiology, University of Texas Southwestern Medical Center, Dallas, Texas.

PLoS Pathog ; 15(2): e1007596, 2019 02.

Article in En | MEDLINE | ID: mdl-30785952

Subject(s)

RNA Helicases/metabolism; RNA Stability/physiology; Viral Regulatory and Accessory Proteins/metabolism; Cell Line; Cell Nucleus; GTPase-Activating Proteins/metabolism; GTPase-Activating Proteins/physiology; Gene Expression Regulation, Viral/genetics; Genes, Viral/genetics; HEK293 Cells; Herpesvirus 8, Human/metabolism; Herpesvirus 8, Human/pathogenicity; Humans; Nuclear Proteins; Poly(A)-Binding Protein I/metabolism; Poly(A)-Binding Protein I/physiology; Protein Binding; RNA Helicases/physiology; RNA Stability/genetics; RNA, Nuclear/physiology; RNA, Viral; RNA-Binding Proteins; Transcription Factors; Viral Proteins/genetics; Viral Proteins/metabolism; Viral Regulatory and Accessory Proteins/physiology; Virus Replication

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Full text: 1 Database: MEDLINE Main subject: RNA Helicases / RNA Stability / Viral Regulatory and Accessory Proteins Type of study: Risk_factors_studies Limits: Humans Language: En Year: 2019 Type: Article

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