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Copper-Catalyzed Oxydifluoroalkylation of Hydroxyl-Containing Alkenes.
Yang, Yanyan; Yuan, Fangyuan; Ren, Xiangwei; Wang, Guangwei; Zhao, Wentao; Tang, Xiangyang; Guo, Minjie.
Affiliation
  • Yang Y; Tianjin Key Laboratory of Molecular Optoelectronic Science, Department of Chemistry, School of Science , Tianjin University , Tianjin 300072 , P. R. China.
  • Yuan F; Tianjin Key Laboratory of Molecular Optoelectronic Science, Department of Chemistry, School of Science , Tianjin University , Tianjin 300072 , P. R. China.
  • Ren X; Tianjin Key Laboratory of Molecular Optoelectronic Science, Department of Chemistry, School of Science , Tianjin University , Tianjin 300072 , P. R. China.
  • Wang G; Tianjin Key Laboratory of Molecular Optoelectronic Science, Department of Chemistry, School of Science , Tianjin University , Tianjin 300072 , P. R. China.
  • Zhao W; Tianjin Key Laboratory of Molecular Optoelectronic Science, Department of Chemistry, School of Science , Tianjin University , Tianjin 300072 , P. R. China.
  • Tang X; Tianjin Key Laboratory of Molecular Optoelectronic Science, Department of Chemistry, School of Science , Tianjin University , Tianjin 300072 , P. R. China.
  • Guo M; Institute for Molecular Design and Synthesis, School of Pharmaceutical Science and Technology , Tianjin University , Tianjin 300072 , P. R. China.
J Org Chem ; 84(7): 4507-4516, 2019 04 05.
Article in En | MEDLINE | ID: mdl-30816034
ABSTRACT
An efficient oxydifluoroalkylation of hydroxyl-containing alkenes using a copper catalytic system has been developed. This reaction proceeded through a one-pot process of difluoroalkylation followed by nucleophilic attack of the appended hydroxyl group. This strategy has the advantages of a low-cost catalyst and broad substrate scope, which provides a facile access to various fluoroalkylated tetrahydrofurans and tetrahydropyrans.
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Full text: 1 Database: MEDLINE Language: En Year: 2019 Type: Article
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Full text: 1 Database: MEDLINE Language: En Year: 2019 Type: Article