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Stem cell persistence in CML is mediated by extrinsically activated JAK1-STAT3 signaling.
Kuepper, Maja Kim; Bütow, Marlena; Herrmann, Oliver; Ziemons, Janine; Chatain, Nicolas; Maurer, Angela; Kirschner, Martin; Maié, Tiago; Costa, Ivan G; Eschweiler, Jörg; Koschmieder, Steffen; Brümmendorf, Tim H; Müller-Newen, Gerhard; Schemionek, Mirle.
Affiliation
  • Kuepper MK; Department of Hematology, Oncology, Hemostaseology, and Stem Cell Transplantation, Faculty of Medicine, RWTH Aachen University, Aachen, Germany.
  • Bütow M; Department of Hematology, Oncology, Hemostaseology, and Stem Cell Transplantation, Faculty of Medicine, RWTH Aachen University, Aachen, Germany.
  • Herrmann O; Department of Hematology, Oncology, Hemostaseology, and Stem Cell Transplantation, Faculty of Medicine, RWTH Aachen University, Aachen, Germany.
  • Ziemons J; Department of Hematology, Oncology, Hemostaseology, and Stem Cell Transplantation, Faculty of Medicine, RWTH Aachen University, Aachen, Germany.
  • Chatain N; Department of Hematology, Oncology, Hemostaseology, and Stem Cell Transplantation, Faculty of Medicine, RWTH Aachen University, Aachen, Germany.
  • Maurer A; Department of Hematology, Oncology, Hemostaseology, and Stem Cell Transplantation, Faculty of Medicine, RWTH Aachen University, Aachen, Germany.
  • Kirschner M; Department of Hematology, Oncology, Hemostaseology, and Stem Cell Transplantation, Faculty of Medicine, RWTH Aachen University, Aachen, Germany.
  • Maié T; Institute for Computational Genomics, Joint Research Center for Computational Biomedicine, RWTH Aachen University, Aachen, Germany.
  • Costa IG; Institute for Computational Genomics, Joint Research Center for Computational Biomedicine, RWTH Aachen University, Aachen, Germany.
  • Eschweiler J; Department of Orthopedics, Aachen University Hospital, Aachen, Germany.
  • Koschmieder S; Department of Hematology, Oncology, Hemostaseology, and Stem Cell Transplantation, Faculty of Medicine, RWTH Aachen University, Aachen, Germany.
  • Brümmendorf TH; Department of Hematology, Oncology, Hemostaseology, and Stem Cell Transplantation, Faculty of Medicine, RWTH Aachen University, Aachen, Germany.
  • Müller-Newen G; Institute of Biochemistry and Molecular Biology, RWTH Aachen University, Aachen, Germany.
  • Schemionek M; Department of Hematology, Oncology, Hemostaseology, and Stem Cell Transplantation, Faculty of Medicine, RWTH Aachen University, Aachen, Germany. mschemionek@ukaachen.de.
Leukemia ; 33(8): 1964-1977, 2019 08.
Article in En | MEDLINE | ID: mdl-30842608
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Full text: 1 Database: MEDLINE Main subject: Neoplastic Stem Cells / Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Signal Transduction / STAT3 Transcription Factor / Janus Kinase 1 Type of study: Prognostic_studies Limits: Animals / Humans Language: En Year: 2019 Type: Article
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Full text: 1 Database: MEDLINE Main subject: Neoplastic Stem Cells / Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Signal Transduction / STAT3 Transcription Factor / Janus Kinase 1 Type of study: Prognostic_studies Limits: Animals / Humans Language: En Year: 2019 Type: Article