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Structure- and Ligand-Based Discovery of Chromane Arylsulfonamide Nav1.7 Inhibitors for the Treatment of Chronic Pain.
McKerrall, Steven J; Nguyen, Teresa; Lai, Kwong Wah; Bergeron, Philippe; Deng, Lunbin; DiPasquale, Antonio; Chang, Jae H; Chen, Jun; Chernov-Rogan, Tania; Hackos, David H; Maher, Jonathan; Ortwine, Daniel F; Pang, Jodie; Payandeh, Jian; Proctor, William R; Shields, Shannon D; Vogt, Jennifer; Ji, Pengfei; Liu, Wenfeng; Ballini, Elisa; Schumann, Lilia; Tarozzo, Glauco; Bankar, Girish; Chowdhury, Sultan; Hasan, Abid; Johnson, J P; Khakh, Kuldip; Lin, Sophia; Cohen, Charles J; Dehnhardt, Christoph M; Safina, Brian S; Sutherlin, Daniel P.
Affiliation
  • McKerrall SJ; Genentech, Inc. , 1 DNA Way , South San Francisco , California 94080 , United States.
  • Nguyen T; Genentech, Inc. , 1 DNA Way , South San Francisco , California 94080 , United States.
  • Lai KW; WuXi AppTec Co., Ltd. , 288 Fute Zhong Road , Waigaoqiao Free Trade Zone, Shanghai 200131 , People's Republic of China.
  • Bergeron P; Genentech, Inc. , 1 DNA Way , South San Francisco , California 94080 , United States.
  • Deng L; Genentech, Inc. , 1 DNA Way , South San Francisco , California 94080 , United States.
  • DiPasquale A; Genentech, Inc. , 1 DNA Way , South San Francisco , California 94080 , United States.
  • Chang JH; Genentech, Inc. , 1 DNA Way , South San Francisco , California 94080 , United States.
  • Chen J; Genentech, Inc. , 1 DNA Way , South San Francisco , California 94080 , United States.
  • Chernov-Rogan T; Genentech, Inc. , 1 DNA Way , South San Francisco , California 94080 , United States.
  • Hackos DH; Genentech, Inc. , 1 DNA Way , South San Francisco , California 94080 , United States.
  • Maher J; Genentech, Inc. , 1 DNA Way , South San Francisco , California 94080 , United States.
  • Ortwine DF; Genentech, Inc. , 1 DNA Way , South San Francisco , California 94080 , United States.
  • Pang J; Genentech, Inc. , 1 DNA Way , South San Francisco , California 94080 , United States.
  • Payandeh J; Genentech, Inc. , 1 DNA Way , South San Francisco , California 94080 , United States.
  • Proctor WR; Genentech, Inc. , 1 DNA Way , South San Francisco , California 94080 , United States.
  • Shields SD; Genentech, Inc. , 1 DNA Way , South San Francisco , California 94080 , United States.
  • Vogt J; Genentech, Inc. , 1 DNA Way , South San Francisco , California 94080 , United States.
  • Ji P; WuXi AppTec Co., Ltd. , 288 Fute Zhong Road , Waigaoqiao Free Trade Zone, Shanghai 200131 , People's Republic of China.
  • Liu W; WuXi AppTec Co., Ltd. , 288 Fute Zhong Road , Waigaoqiao Free Trade Zone, Shanghai 200131 , People's Republic of China.
  • Ballini E; Evotec AG , Essener Bogen 7 , 22419 Hamburg , Germany.
  • Schumann L; Evotec AG , Essener Bogen 7 , 22419 Hamburg , Germany.
  • Tarozzo G; Evotec AG , Essener Bogen 7 , 22419 Hamburg , Germany.
  • Bankar G; Xenon Pharmaceuticals, Inc. , 200-3650 Gilmore Way , Burnaby , British Columbia V5G 4W8 , Canada.
  • Chowdhury S; Xenon Pharmaceuticals, Inc. , 200-3650 Gilmore Way , Burnaby , British Columbia V5G 4W8 , Canada.
  • Hasan A; Xenon Pharmaceuticals, Inc. , 200-3650 Gilmore Way , Burnaby , British Columbia V5G 4W8 , Canada.
  • Johnson JP; Xenon Pharmaceuticals, Inc. , 200-3650 Gilmore Way , Burnaby , British Columbia V5G 4W8 , Canada.
  • Khakh K; Xenon Pharmaceuticals, Inc. , 200-3650 Gilmore Way , Burnaby , British Columbia V5G 4W8 , Canada.
  • Lin S; Xenon Pharmaceuticals, Inc. , 200-3650 Gilmore Way , Burnaby , British Columbia V5G 4W8 , Canada.
  • Cohen CJ; Xenon Pharmaceuticals, Inc. , 200-3650 Gilmore Way , Burnaby , British Columbia V5G 4W8 , Canada.
  • Dehnhardt CM; Xenon Pharmaceuticals, Inc. , 200-3650 Gilmore Way , Burnaby , British Columbia V5G 4W8 , Canada.
  • Safina BS; Genentech, Inc. , 1 DNA Way , South San Francisco , California 94080 , United States.
  • Sutherlin DP; Genentech, Inc. , 1 DNA Way , South San Francisco , California 94080 , United States.
J Med Chem ; 62(8): 4091-4109, 2019 04 25.
Article in En | MEDLINE | ID: mdl-30943032
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Full text: 1 Database: MEDLINE Main subject: Sulfonamides / NAV1.7 Voltage-Gated Sodium Channel / Voltage-Gated Sodium Channel Blockers Limits: Animals / Humans / Male Language: En Year: 2019 Type: Article
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Full text: 1 Database: MEDLINE Main subject: Sulfonamides / NAV1.7 Voltage-Gated Sodium Channel / Voltage-Gated Sodium Channel Blockers Limits: Animals / Humans / Male Language: En Year: 2019 Type: Article