[Surgery and the acquired inhibitor of factor VIII coagulant]. / Chirurgie et inhibiteur acquis du facteur VIII coagulant.

ABSTRACT

A case is reported of an 80 year old woman with old sarcoidosis and acquired factor VIIIc inhibitor undergoing orthopaedic surgery. This was successfully carried out after she had been given a total of 48,420 units of factor VIII concentrate there were no haemorrhagic complications. The main pathological states in which acquired factor VIIIc inhibitor may be found are related principal treatments available nowadays are discussed immunosuppressors, human factor VIII, animal factor VIII, prothrombin complex concentrate, plasma exchange.