Compounds of PAH mixtures dependent interaction between multiple signaling pathways in granulosa tumour cells.

Zajda, K; Rak, A; Ptak, A; Gregoraszczuk, E L

Zajda, K; Rak, A; Ptak, A; Gregoraszczuk, E L.

Affiliation

Zajda K; Department of Physiology and Toxicology of Reproduction, Institute of Zoology and Biomedical Research, Jagiellonian University in Kraków, Poland.
Rak A; Department of Physiology and Toxicology of Reproduction, Institute of Zoology and Biomedical Research, Jagiellonian University in Kraków, Poland.
Ptak A; Department of Physiology and Toxicology of Reproduction, Institute of Zoology and Biomedical Research, Jagiellonian University in Kraków, Poland.
Gregoraszczuk EL; Department of Physiology and Toxicology of Reproduction, Institute of Zoology and Biomedical Research, Jagiellonian University in Kraków, Poland. Electronic address: ewa.gregoraszczuk@uj.edu.pl.

Toxicol Lett ; 310: 14-22, 2019 Aug.

Article in En | MEDLINE | ID: mdl-30980910

Subject(s)

Complex Mixtures/toxicity; Granulosa Cell Tumor; Granulosa Cells/drug effects; Ovarian Neoplasms; Polycyclic Aromatic Hydrocarbons/toxicity; Signal Transduction/drug effects; Basic Helix-Loop-Helix Transcription Factors/genetics; Basic Helix-Loop-Helix Transcription Factors/metabolism; Cell Line, Tumor; Cell Proliferation/drug effects; Cytochrome P-450 CYP1A1/genetics; Cytochrome P-450 CYP1A1/metabolism; Energy Metabolism/drug effects; Estrogen Receptor alpha/genetics; Estrogen Receptor alpha/metabolism; Female; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic/drug effects; Granulosa Cell Tumor/genetics; Granulosa Cell Tumor/metabolism; Granulosa Cell Tumor/pathology; Granulosa Cells/metabolism; Granulosa Cells/pathology; Humans; Mitochondria/drug effects; Mitochondria/metabolism; NF-kappa B p52 Subunit/genetics; NF-kappa B p52 Subunit/metabolism; Ovarian Neoplasms/genetics; Ovarian Neoplasms/metabolism; Ovarian Neoplasms/pathology; Receptors, Aryl Hydrocarbon/genetics; Receptors, Aryl Hydrocarbon/metabolism; Repressor Proteins/genetics; Repressor Proteins/metabolism

Key words

AhR/ARNT/AhRR/ER/AR/NFκB; Granulosa tumor cell lines; PAH mixture; Signaling pathway

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Full text: 1 Database: MEDLINE Main subject: Ovarian Neoplasms / Polycyclic Aromatic Hydrocarbons / Signal Transduction / Complex Mixtures / Granulosa Cell Tumor / Granulosa Cells Limits: Female / Humans Language: En Year: 2019 Type: Article

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