The influence of storage relative humidity on aerosolization of co-spray dried powders of hygroscopic kanamycin with the hydrophobic drug rifampicin.

Momin, Mohammad A M; Tucker, Ian G; Das, Shyamal C.

Affiliation

Drug Dev Ind Pharm ; 45(7): 1205-1213, 2019 Jul.

Article in En | MEDLINE | ID: mdl-30990097

Subject(s)

Aerosols/chemistry; Kanamycin/chemistry; Powders/chemistry; Rifampin/chemistry; Administration, Inhalation; Calorimetry, Differential Scanning/methods; Chemistry, Pharmaceutical/methods; Dry Powder Inhalers/methods; Excipients/chemistry; Humidity; Hydrophobic and Hydrophilic Interactions; Microscopy, Electron, Scanning/methods; Particle Size; Surface Properties/drug effects; Wettability; X-Ray Diffraction/methods

Key words

Humidity; aerosolization; hydrophobic; hygroscopic; kanamycin; rifampicin; spray-drying; storage