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Absolute basophil count is associated with time to recurrence in patients with high-grade T1 bladder cancer receiving bacillus Calmette-Guérin after transurethral resection of the bladder tumor.
Ferro, M; Di Lorenzo, G; Vartolomei, M D; Bruzzese, D; Cantiello, F; Lucarelli, G; Musi, G; Di Stasi, S; Hurle, R; Guazzoni, G; Busetto, G M; Gabriele, A; Del Giudice, F; Damiano, R; Perri, F; Perdona, S; Verze, P; Borghesi, M; Schiavina, R; Almeida, G L; Bove, P; Lima, E; Autorino, R; Crisan, N; Farhan, A R Abu; Battaglia, M; Russo, G I; Ieluzzi, Vincenzo; Morgia, G; De Placido, P; Terracciano, D; Cimmino, A; Scafuri, L; Mirone, V; De Cobelli, O; Shariat, S; Sonpavde, Guru; Buonerba, C.
Affiliation
  • Ferro M; Division of Urology, European Institute of Oncology, via Ripamonti 435, Milan, Italy. matteo.ferro@ieo.it.
  • Di Lorenzo G; Department of Clinical Medicine and Surgery, Federico II University of Naples, Naples, Italy.
  • Vartolomei MD; Department of Medicine, Università degli Studi del Molise, Campobasso, Italy.
  • Bruzzese D; Division of Urology, European Institute of Oncology, via Ripamonti 435, Milan, Italy.
  • Cantiello F; Department of Cell and Molecular Biology, University of Medicine and Pharmacy, Tirgu Mures, Romania.
  • Lucarelli G; Department of Public Health, Federico II University of Naples, Naples, Italy.
  • Musi G; Department of Urology, Magna Graecia University of Catanzaro, Catanzaro, Italy.
  • Di Stasi S; Department of Emergency and Organ Transplantation, Urology, Andrology and Kidney Transplantation Unit, University of Bari, Bari, Italy.
  • Hurle R; Division of Urology, European Institute of Oncology, via Ripamonti 435, Milan, Italy.
  • Guazzoni G; Department of Experimental Medicine and Surgery, Tor Vegata University, Rome, Italy.
  • Busetto GM; Department of Urology, Istituto Clinico Humanitas Istituto di Ricovero e Cura a Carattere Scientifico-Clinical and Research Hospital, Milan, Italy.
  • Gabriele A; Department of Biomedical Science, Humanitas University, Milan, Rozzano, Italy.
  • Del Giudice F; Department of Urology, Sapienza University of Rome, Rome, Italy.
  • Damiano R; Department of Urology, Sapienza University of Rome, Rome, Italy.
  • Perri F; Department of Urology, Sapienza University of Rome, Rome, Italy.
  • Perdona S; Department of Urology, Magna Graecia University of Catanzaro, Catanzaro, Italy.
  • Verze P; Uro-Gynecological Department, Istituto Nazionale per lo Studio e la Cura dei Tumori, Fondazione "G. Pascale" IRCCS, Naples, Italy.
  • Borghesi M; Uro-Gynecological Department, Istituto Nazionale per lo Studio e la Cura dei Tumori, Fondazione "G. Pascale" IRCCS, Naples, Italy.
  • Schiavina R; Department of Neurosciences, Sciences of Reproduction and Odontostomatology, Urology Unit, University of Naples "Federico II", Naples, Italy.
  • Almeida GL; Department of Urology, University of Bologna, Bologna, Italy.
  • Bove P; Department of Urology, University of Bologna, Bologna, Italy.
  • Lima E; Departamento de Urologia, University of Vale do Itajaí, Itajaí, Brazil.
  • Autorino R; Division of Urology, Department of Experimental Medicine and Surgery, Urology Unit, Tor Vergata University of Rome, Rome, Italy.
  • Crisan N; Life and Health Sciences Research Institute, University of Minho, Braga, Portugal.
  • Farhan ARA; Division of Urology, Virginia Commonwealth University, Richmond, VA, USA.
  • Battaglia M; Department of Urology, University of Medicine and Pharmacy "Iuliu Hateganu,", Cluj-Napoca, Romania.
  • Russo GI; Department of Urology, Magna Graecia University of Catanzaro, Catanzaro, Italy.
  • Ieluzzi V; Department of Emergency and Organ Transplantation, Urology, Andrology and Kidney Transplantation Unit, University of Bari, Bari, Italy.
  • Morgia G; Department of Urology, University of Catania, Catania, Italy.
  • De Placido P; Department of Clinical Medicine and Surgery, Federico II University of Naples, Naples, Italy.
  • Terracciano D; Department of Urology, University of Catania, Catania, Italy.
  • Cimmino A; Department of Clinical Medicine and Surgery, Federico II University of Naples, Naples, Italy.
  • Scafuri L; Department of Translational Medical Sciences, University of Naples "Federico II", Naples, Italy.
  • Mirone V; Institute of Genetics and Biophysics "A. Buzzati-Traverso", CNR, Naples, Italy.
  • De Cobelli O; Department of Clinical Medicine and Surgery, Federico II University of Naples, Naples, Italy.
  • Shariat S; Department of Neurosciences, Sciences of Reproduction and Odontostomatology, Urology Unit, University of Naples "Federico II", Naples, Italy.
  • Sonpavde G; Division of Urology, European Institute of Oncology, via Ripamonti 435, Milan, Italy.
  • Buonerba C; Department of Urology, Medical University of Vienna, Vienna, Austria.
World J Urol ; 38(1): 143-150, 2020 Jan.
Article in En | MEDLINE | ID: mdl-30993426
ABSTRACT

BACKGROUND:

Basophils, eosinophils and monocytes may be involved in BCG-induced immune responses and be associated with outcomes of bladder cancer patients receiving intravesical BCG. Our objective was to explore the association of baseline counts of basophils, eosinophils and monocytes with outcomes of patients with high-grade T1 bladder cancer receiving a standard course of intravesical BCG.

METHODS:

We retrospectively reviewed medical records of patients with primary T1 HG/G3 bladder cancer. After re-TURBT, patients were treated with a 6-week course of intravesical BCG induction followed by intravesical BCG every week for 3 weeks given at 3, 6, 12, 18, 24, 30 and 36 months from initiation of therapy The analysis of potential risk factors for recurrence, muscle invasion and cancer-specific and overall survival was performed using univariable Cox regression models. Those factors that presented, at univariate analysis, an association with the event at a liberal p < 0.1, have been selected for the development of a multivariable model.

RESULTS:

A total of 1045 patients with primary T1 HG/G3 were included. A total of 678 (64.9%) recurrences, 303 (29.0%) progressions and 150 (14.3%) deaths were observed during follow-up. Multivariate analysis showed that logarithmic transformation of basophils count was associated with a 30% increment in the hazard of recurrence per unit increase of logarithmic basophils count (HR 1.30; 95% confidence interval 1.09-1.54; p = 0.0026). Basophil count modeled by quartiles was also significantly associated with time to recurrence [second vs. lower quartile HR 1.42 (1.12-1.79); p = 0.003, third vs. lower quartile HR 1.26 (1.01-1.57); p = 0.041; upper vs. lower quartile HR 1.36 (1.1-1.68); p = 0.005]. The limitations of a retrospective study are applicable.

CONCLUSION:

Baseline basophil count may predict recurrence in BCG-treated HG/G3 T1 bladder cancer patients. External validation is warranted.
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Full text: 1 Database: MEDLINE Main subject: Basophils / Urinary Bladder Neoplasms / BCG Vaccine / Cystectomy / Neoplasm Recurrence, Local / Neoplasm Staging / Neutrophils Type of study: Observational_studies / Prognostic_studies / Risk_factors_studies Limits: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Language: En Year: 2020 Type: Article
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Full text: 1 Database: MEDLINE Main subject: Basophils / Urinary Bladder Neoplasms / BCG Vaccine / Cystectomy / Neoplasm Recurrence, Local / Neoplasm Staging / Neutrophils Type of study: Observational_studies / Prognostic_studies / Risk_factors_studies Limits: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Language: En Year: 2020 Type: Article