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2'-O-methylation within prokaryotic and eukaryotic tRNA inhibits innate immune activation by endosomal Toll-like receptors but does not affect recognition of whole organisms.
Freund, Isabel; Buhl, Daniel K; Boutin, Sébastien; Kotter, Annika; Pichot, Florian; Marchand, Virginie; Vierbuchen, Tim; Heine, Holger; Motorin, Yuri; Helm, Mark; Dalpke, Alexander H; Eigenbrod, Tatjana.
Affiliation
  • Freund I; Department of Infectious Diseases, Medical Microbiology and Hygiene, Heidelberg University Hospital, 69120 Heidelberg, Germany.
  • Buhl DK; Department of Infectious Diseases, Medical Microbiology and Hygiene, Heidelberg University Hospital, 69120 Heidelberg, Germany.
  • Boutin S; Department of Infectious Diseases, Medical Microbiology and Hygiene, Heidelberg University Hospital, 69120 Heidelberg, Germany.
  • Kotter A; Institute of Pharmacy and Biochemistry, Johannes Gutenberg-University Mainz, 55128 Mainz, Germany.
  • Pichot F; Institute of Pharmacy and Biochemistry, Johannes Gutenberg-University Mainz, 55128 Mainz, Germany.
  • Marchand V; IMoPA UMR7365 CNRS-Lorraine University, BioPole Lorraine University, 54500 Vandoeuvre-les-Nancy, France.
  • Vierbuchen T; UMS2008 IBSLor, CNRS-Lorraine University-INSERM, BioPole Lorraine University, 54500 Vandoeuvre-les-Nancy, France.
  • Heine H; Division of Innate Immunity, Research Center Borstel, 23845 Borstel, Germany.
  • Motorin Y; Division of Innate Immunity, Research Center Borstel, 23845 Borstel, Germany.
  • Helm M; IMoPA UMR7365 CNRS-Lorraine University, BioPole Lorraine University, 54500 Vandoeuvre-les-Nancy, France.
  • Dalpke AH; Institute of Pharmacy and Biochemistry, Johannes Gutenberg-University Mainz, 55128 Mainz, Germany.
  • Eigenbrod T; Department of Infectious Diseases, Medical Microbiology and Hygiene, Heidelberg University Hospital, 69120 Heidelberg, Germany.
RNA ; 25(7): 869-880, 2019 07.
Article in En | MEDLINE | ID: mdl-31019095
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Full text: 1 Database: MEDLINE Main subject: Prokaryotic Cells / Endosomes / RNA, Transfer / Toll-Like Receptors / Eukaryotic Cells / Guanosine / Immunity, Innate Limits: Humans Language: En Year: 2019 Type: Article
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Full text: 1 Database: MEDLINE Main subject: Prokaryotic Cells / Endosomes / RNA, Transfer / Toll-Like Receptors / Eukaryotic Cells / Guanosine / Immunity, Innate Limits: Humans Language: En Year: 2019 Type: Article