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Synthesis, X-ray Analysis, Biological Evaluation and Molecular Docking Study of New Thiazoline Derivatives.
Mabkhot, Yahia N; Algarni, H; Alsayari, Abdulrhman; Bin Muhsinah, Abdullatif; Kheder, Nabila A; Almarhoon, Zainab M; Al-Aizari, Faiz A.
Affiliation
  • Mabkhot YN; Department of Pharmaceutical Chemistry, College of Pharmacy, King Khalid University, Abha 61441, Saudi Arabia. ygaber@kku.edu.sa.
  • Algarni H; Department of Physics, Faculty of Sciences, King Khalid University, P.O. Box 9004, Abha 61441, Saudi Arabia. halgarni@kku.edu.sa.
  • Alsayari A; Research Centre for Advanced Materials Science (RCAMS), King Khalid University, P.O. Box 9004, Abha 61441, Saudi Arabia. halgarni@kku.edu.sa.
  • Bin Muhsinah A; Department of Pharmacognosy, College of Pharmacy, King Khalid University, Abha 61441, Saudi Arabia. alsayari@kku.edu.sa.
  • Kheder NA; Department of Pharmacognosy, College of Pharmacy, King Khalid University, Abha 61441, Saudi Arabia. ajmohsnah@kku.edu.sa.
  • Almarhoon ZM; Department of Chemistry, Faculty of Science, Cairo University, Giza 12613, Egypt. nabila.abdelshafy@gmail.com.
  • Al-Aizari FA; Department of Chemistry, College of Science, King Saud University, P.O. Box 2455, Riyadh 11451, Saudi Arabia. zalmarhoon@ksu.edu.sa.
Molecules ; 24(9)2019 Apr 26.
Article in En | MEDLINE | ID: mdl-31035531
ABSTRACT
A series of new thiazoline derivatives were synthesized. Structure analyses were accomplished employing 1H-NMR, 13C-NMR, X-ray and MS techniques. The in vitro antitumor activities were assessed against human hepatocellular carcinoma (HepG-2) and colorectal carcinoma (HCT-116) cell lines. The results revealed that the thiazolines 5b and 2c exhibited significant activity against the two cell lines. The in vitro antimicrobial screening showed that the thiazolines 2c, 5b and 5d showed promising inhibition activity against Salmonella sp. Additionally, the inhibition activity of thiazolines 2e and 5b against Escherichia coli was comparable to that of the reference compound gentamycin.
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Full text: 1 Database: MEDLINE Main subject: Organic Chemicals / Chemistry Techniques, Synthetic / Molecular Docking Simulation Limits: Humans Language: En Year: 2019 Type: Article
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PubMed Links
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Full text: 1 Database: MEDLINE Main subject: Organic Chemicals / Chemistry Techniques, Synthetic / Molecular Docking Simulation Limits: Humans Language: En Year: 2019 Type: Article