Refractory myasthenia gravis: Characteristics of a portuguese cohort.
Muscle Nerve
; 60(2): 188-191, 2019 08.
Article
in En
| MEDLINE
| ID: mdl-31050006
ABSTRACT
INTRODUCTION:
Some myasthenia gravis (MG) patients are refractory to conventional treatments.METHODS:
To describe the clinical features of refractory MG (RMG) and explore the association with human leukocyte antigen HLA-DRB1 alleles, a cohort study of 114 consecutive MG patients was performed. Patients were classified as RMG based on predefined criteria.RESULTS:
Twenty-two patients were found to have RMG (19.3%). There were no differences between non-RMG and RMG patients with respect to sex, age of onset, abnormal 3-Hz repetitive nerve stimulation, anti-acetylcholine receptor antibody positivity, thymectomy, thymoma or thymic hyperplasia, and polyautoimmunity. HLA-DRB1*03 was more frequent in the non-RMG vs. control population (P = 3 × 10-6 ). The HLA-DRB1*13 allele was less frequent in non-RMG patients compared with controls (P = 0.002), and less frequent in the non-RMG group compared with the RMG group (P = 0.003).DISCUSSION:
HLA-DRB1*03 was more common in non-RMG, and the HLA-DRB1*13 allele appeared to have a protective role, as reported previously in other autoimmune disorders. Muscle Nerve 60 188-191, 2019.Key words
Full text:
1
Database:
MEDLINE
Main subject:
HLA-DRB1 Chains
/
Myasthenia Gravis
Type of study:
Etiology_studies
/
Incidence_studies
/
Observational_studies
/
Risk_factors_studies
Limits:
Adult
/
Female
/
Humans
/
Male
/
Middle aged
Country/Region as subject:
Europa
Language:
En
Year:
2019
Type:
Article