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Selenium Drives a Transcriptional Adaptive Program to Block Ferroptosis and Treat Stroke.
Alim, Ishraq; Caulfield, Joseph T; Chen, Yingxin; Swarup, Vivek; Geschwind, Daniel H; Ivanova, Elena; Seravalli, Javier; Ai, Youxi; Sansing, Lauren H; Ste Marie, Emma J; Hondal, Robert J; Mukherjee, Sushmita; Cave, John W; Sagdullaev, Botir T; Karuppagounder, Saravanan S; Ratan, Rajiv R.
Affiliation
  • Alim I; Sperling Center for Hemorrhagic Stroke Recovery, Burke Neurological Institute at Weill Cornell Medicine, White Plains, NY 10605, USA; Feil Family Brain and Mind Research Institute, Weill Cornell Medicine, New York, NY 10065, USA.
  • Caulfield JT; Sperling Center for Hemorrhagic Stroke Recovery, Burke Neurological Institute at Weill Cornell Medicine, White Plains, NY 10605, USA; Feil Family Brain and Mind Research Institute, Weill Cornell Medicine, New York, NY 10065, USA.
  • Chen Y; Sperling Center for Hemorrhagic Stroke Recovery, Burke Neurological Institute at Weill Cornell Medicine, White Plains, NY 10605, USA; Feil Family Brain and Mind Research Institute, Weill Cornell Medicine, New York, NY 10065, USA.
  • Swarup V; Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA; Department of Neurobiology and Behavior, University of California, Irvine, Irvine, CA 92697, USA; Institute for Memory Impairments and Neurological Disorders (UCI MIND), Irvin
  • Geschwind DH; Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA.
  • Ivanova E; Sperling Center for Hemorrhagic Stroke Recovery, Burke Neurological Institute at Weill Cornell Medicine, White Plains, NY 10605, USA; Feil Family Brain and Mind Research Institute, Weill Cornell Medicine, New York, NY 10065, USA.
  • Seravalli J; Redox Biology Center and Department of Biochemistry, University of Nebraska, Lincoln, NE 68588, USA.
  • Ai Y; Department of Neurology, Yale University School of Medicine, New Haven, CT 06510, USA.
  • Sansing LH; Department of Neurology, Yale University School of Medicine, New Haven, CT 06510, USA.
  • Ste Marie EJ; Department of Biochemistry, University of Vermont, Burlington, VT 05405, USA.
  • Hondal RJ; Department of Biochemistry, University of Vermont, Burlington, VT 05405, USA.
  • Mukherjee S; Department of Biochemistry, Weill Cornell Medicine, New York, NY 10065, USA.
  • Cave JW; Sperling Center for Hemorrhagic Stroke Recovery, Burke Neurological Institute at Weill Cornell Medicine, White Plains, NY 10605, USA; Feil Family Brain and Mind Research Institute, Weill Cornell Medicine, New York, NY 10065, USA.
  • Sagdullaev BT; Sperling Center for Hemorrhagic Stroke Recovery, Burke Neurological Institute at Weill Cornell Medicine, White Plains, NY 10605, USA; Feil Family Brain and Mind Research Institute, Weill Cornell Medicine, New York, NY 10065, USA.
  • Karuppagounder SS; Sperling Center for Hemorrhagic Stroke Recovery, Burke Neurological Institute at Weill Cornell Medicine, White Plains, NY 10605, USA; Feil Family Brain and Mind Research Institute, Weill Cornell Medicine, New York, NY 10065, USA.
  • Ratan RR; Sperling Center for Hemorrhagic Stroke Recovery, Burke Neurological Institute at Weill Cornell Medicine, White Plains, NY 10605, USA; Feil Family Brain and Mind Research Institute, Weill Cornell Medicine, New York, NY 10065, USA. Electronic address: rrr2001@med.cornell.edu.
Cell ; 177(5): 1262-1279.e25, 2019 05 16.
Article in En | MEDLINE | ID: mdl-31056284
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Full text: 1 Database: MEDLINE Main subject: Selenium / Transcription, Genetic / Gene Expression Regulation, Enzymologic / Brain Ischemia / Stroke / Intracranial Hemorrhages / Cell-Penetrating Peptides / Ferroptosis / Phospholipid Hydroperoxide Glutathione Peroxidase / Neurons Type of study: Prognostic_studies Limits: Animals / Humans / Male Language: En Year: 2019 Type: Article
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Full text: 1 Database: MEDLINE Main subject: Selenium / Transcription, Genetic / Gene Expression Regulation, Enzymologic / Brain Ischemia / Stroke / Intracranial Hemorrhages / Cell-Penetrating Peptides / Ferroptosis / Phospholipid Hydroperoxide Glutathione Peroxidase / Neurons Type of study: Prognostic_studies Limits: Animals / Humans / Male Language: En Year: 2019 Type: Article