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Somatic mutations and promotor methylation of the ryanodine receptor 2 is a common event in the pathogenesis of head and neck cancer.
Schmitt, Katrin; Molfenter, Britta; Laureano, Natalia Koerich; Tawk, Bouchra; Bieg, Matthias; Hostench, Xavier Pastor; Weichenhan, Dieter; Ullrich, Nina D; Shang, Viny; Richter, Daniela; Stögbauer, Fabian; Schroeder, Lea; de Bem Prunes, Bianca; Visioli, Fernanda; Rados, Pantelis Varvaki; Jou, Adriana; Plath, Michaela; Federspil, Philippe A; Thierauf, Julia; Döscher, Johannes; Weissinger, Stephanie E; Hoffmann, Thomas K; Wagner, Steffen; Wittekindt, Claus; Ishaque, Naveed; Eils, Roland; Klussmann, Jens P; Holzinger, Dana; Plass, Christoph; Abdollahi, Amir; Freier, Kolja; Weichert, Wilko; Zaoui, Karim; Hess, Jochen.
Affiliation
  • Schmitt K; Department of Otorhinolaryngology, Head and Neck Surgery, Heidelberg University Hospital, Heidelberg, Germany.
  • Molfenter B; Department of Otorhinolaryngology, Head and Neck Surgery, Heidelberg University Hospital, Heidelberg, Germany.
  • Laureano NK; Department of Otorhinolaryngology, Head and Neck Surgery, Heidelberg University Hospital, Heidelberg, Germany.
  • Tawk B; Molecular Mechanisms of Head and Neck Tumors, German Cancer Research Center (DKFZ), Heidelberg, Germany.
  • Bieg M; Oral Pathology, Federal University of Rio Grande do Sul (UFRGS), Porto Alegre, Brazil.
  • Hostench XP; Division of Molecular and Translational Radiation Oncology, Heidelberg Ion Therapy Center (HIT), Heidelberg Institute of Radiation Oncology (HIRO), Heidelberg University Hospital, and Translational Radiation Oncology, German Cancer Consortium (DKTK), National Center for Tumor Diseases (NCT), German
  • Weichenhan D; Division of Theoretical Bioinformatics, German Cancer Research Center (DKFZ), and Heidelberg Center for Personalized Oncology (DKFZ-HIPO), Heidelberg, Germany.
  • Ullrich ND; Division of Theoretical Bioinformatics, German Cancer Research Center (DKFZ), and Heidelberg Center for Personalized Oncology (DKFZ-HIPO), Heidelberg, Germany.
  • Shang V; Cancer Epigenomics, German Cancer Research Center (DKFZ), Heidelberg, Germany.
  • Richter D; Institute of Physiology and Pathophysiology, Division of Cardiovascular Physiology, Heidelberg University, Heidelberg, Germany.
  • Stögbauer F; Department of Otorhinolaryngology, Head and Neck Surgery, Heidelberg University Hospital, Heidelberg, Germany.
  • Schroeder L; Translational Medical Oncology, National Center for Tumor Diseases (NCT) Dresden, Dresden and German Cancer Research Center (DKFZ), Heidelberg, Germany.
  • de Bem Prunes B; Institute of Pathology, Heidelberg University Hospital, Heidelberg, Germany.
  • Visioli F; Division of Molecular Diagnostics of Oncogenic Infections, Infection, Inflammation and Cancer Program, German Cancer Research Center (DKFZ), Heidelberg, Germany.
  • Rados PV; Oral Pathology, Federal University of Rio Grande do Sul (UFRGS), Porto Alegre, Brazil.
  • Jou A; Oral Pathology, Federal University of Rio Grande do Sul (UFRGS), Porto Alegre, Brazil.
  • Plath M; Oral Pathology, Federal University of Rio Grande do Sul (UFRGS), Porto Alegre, Brazil.
  • Federspil PA; Department of Otorhinolaryngology, Head and Neck Surgery, Heidelberg University Hospital, Heidelberg, Germany.
  • Thierauf J; Molecular Mechanisms of Head and Neck Tumors, German Cancer Research Center (DKFZ), Heidelberg, Germany.
  • Döscher J; Department of Otorhinolaryngology, Head and Neck Surgery, Heidelberg University Hospital, Heidelberg, Germany.
  • Weissinger SE; Department of Otorhinolaryngology, Head and Neck Surgery, Heidelberg University Hospital, Heidelberg, Germany.
  • Hoffmann TK; Department of Otorhinolaryngology, Head and Neck Surgery, Heidelberg University Hospital, Heidelberg, Germany.
  • Wagner S; Department of Otorhinolaryngology, Head and Neck Surgery, University Medical Center Ulm, Ulm, Germany.
  • Wittekindt C; Institute of Pathology, University Hospital Ulm, Ulm, Germany.
  • Ishaque N; Department of Otorhinolaryngology, Head and Neck Surgery, University Medical Center Ulm, Ulm, Germany.
  • Eils R; Department of Otorhinolaryngology, Head and Neck Surgery, University of Giessen, Giessen, Germany.
  • Klussmann JP; Department of Otorhinolaryngology, Head and Neck Surgery, University of Giessen, Giessen, Germany.
  • Holzinger D; Division of Theoretical Bioinformatics, German Cancer Research Center (DKFZ), and Heidelberg Center for Personalized Oncology (DKFZ-HIPO), Heidelberg, Germany.
  • Plass C; Division of Theoretical Bioinformatics, German Cancer Research Center (DKFZ), and Heidelberg Center for Personalized Oncology (DKFZ-HIPO), Heidelberg, Germany.
  • Abdollahi A; Department of Otorhinolaryngology, Head and Neck Surgery, University of Cologne, Cologne, Germany.
  • Freier K; Division of Molecular Diagnostics of Oncogenic Infections, Infection, Inflammation and Cancer Program, German Cancer Research Center (DKFZ), Heidelberg, Germany.
  • Weichert W; Cancer Epigenomics, German Cancer Research Center (DKFZ), Heidelberg, Germany.
  • Zaoui K; Division of Molecular and Translational Radiation Oncology, Heidelberg Ion Therapy Center (HIT), Heidelberg Institute of Radiation Oncology (HIRO), Heidelberg University Hospital, and Translational Radiation Oncology, German Cancer Consortium (DKTK), National Center for Tumor Diseases (NCT), German
  • Hess J; Department of Oral and Maxillofacial Surgery, Heidelberg University Hospital, Heidelberg, Germany.
Int J Cancer ; 145(12): 3299-3310, 2019 12 15.
Article in En | MEDLINE | ID: mdl-31135957
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Full text: 1 Database: MEDLINE Main subject: Promoter Regions, Genetic / DNA Methylation / Ryanodine Receptor Calcium Release Channel / Head and Neck Neoplasms / Mutation Type of study: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limits: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Language: En Year: 2019 Type: Article
Fulltext
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Full text: 1 Database: MEDLINE Main subject: Promoter Regions, Genetic / DNA Methylation / Ryanodine Receptor Calcium Release Channel / Head and Neck Neoplasms / Mutation Type of study: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limits: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Language: En Year: 2019 Type: Article