Removal of DHT can relieve polycystic ovarian but not metabolic abnormalities in DHT-induced hyperandrogenism in mice.
Reprod Fertil Dev
; 31(10): 1597-1606, 2019 Sep.
Article
in En
| MEDLINE
| ID: mdl-31142430
ABSTRACT
Polycystic ovary syndrome (PCOS) is an endocrine disorder with a high prevalence in women of childbearing age. To date, there is no method of efficiently diagnosing PCOS and curing it completely because its pathomechanism remains unclear. Here, we investigated whether metabolic abnormalities maintain the hyperandrogenism and PCOS-like ovaries and whether the symptoms induced by excess androgen are treatable. We ceased the abnormal dihydrotestosterone (DHT) stimulation to determine changes in PCOS-like mice. After ceasing DHT stimulation, the ovarian morphology and gene expression recovered from the DHT-stimulated status. However, after cessation of DHT stimulation, the hypertrophy of adipose tissues and hepatic steatosis were not significantly restored, and fat accumulation-related gene expression and serum metabolic markers in the mice were altered. These findings showed that the reproductive dysfunction was obviously relieved, but because the metabolic abnormalities were not relieved after the cessation of excess androgen for 30 days, it appears that the latter may not maintain the former.
Full text:
1
Database:
MEDLINE
Main subject:
Polycystic Ovary Syndrome
/
Dihydrotestosterone
/
Hyperandrogenism
/
Metabolic Syndrome
Type of study:
Prognostic_studies
/
Risk_factors_studies
Limits:
Animals
Language:
En
Year:
2019
Type:
Article