Mutagenicity and recombinogenicity evaluation of bupropion hydrochloride and trazodone hydrochloride in somatic cells of Drosophila melanogaster.

Naves, Maria Paula Carvalho; de Morais, Cássio Resende; Spanó, Mário Antônio; de Rezende, Alexandre Azenha Alves

Naves, Maria Paula Carvalho; de Morais, Cássio Resende; Spanó, Mário Antônio; de Rezende, Alexandre Azenha Alves.

Affiliation

Naves MPC; Institute of Genetics and Biochemistry, Federal University of Uberlândia, Campus Umuarama, 38400-902, Uberlândia, Minas Gerais, Brazil.
de Morais CR; Institute of Genetics and Biochemistry, Federal University of Uberlândia, Campus Umuarama, 38400-902, Uberlândia, Minas Gerais, Brazil.
Spanó MA; Institute of Genetics and Biochemistry, Federal University of Uberlândia, Campus Umuarama, 38400-902, Uberlândia, Minas Gerais, Brazil.
de Rezende AAA; Institute of Genetics and Biochemistry, Federal University of Uberlândia, Campus Umuarama, 38400-902, Uberlândia, Minas Gerais, Brazil; Institute of Exact and Natural Sciences of Pontal, Federal University of Uberlândia, Campus Pontal, 38304-402, Ituiutaba, Minas Gerais, Brazil. Electronic address:

Food Chem Toxicol ; 131: 110557, 2019 Sep.

Article in En | MEDLINE | ID: mdl-31176925

Subject(s)

Antidepressive Agents/toxicity; Bupropion/toxicity; Drosophila melanogaster/drug effects; Mutagens/toxicity; Recombination, Genetic/drug effects; Trazodone/toxicity; Animals; Drosophila melanogaster/genetics; Female; Male; Mutagenicity Tests; Mutation; Wings, Animal/drug effects

Key words

Antidepressants; SMART; Somatic mutation and recombination test; Toxicity

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Full text: 1 Database: MEDLINE Main subject: Recombination, Genetic / Trazodone / Bupropion / Drosophila melanogaster / Mutagens / Antidepressive Agents Limits: Animals Language: En Year: 2019 Type: Article

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