Co3O4 nanoparticles supported mesoporous carbon framework interface for glucose biosensing.
Talanta
; 203: 112-121, 2019 Oct 01.
Article
in En
| MEDLINE
| ID: mdl-31202315
ABSTRACT
The present work reports the preparation of advanced functional nanostructures based on cobalt oxide supported mesoporous carbon framework (Co3O4@MCF) for electrochemical biosensing. Co3O4@MCF was synthesized by simple hythrothermal & pyrolysis method and further characterized by various microscopic and spectroscopic techniques. The transmission electron microscopic (TEM) images show the lattice fringes of crystalline Co3O4 with interlayer spacing of 0.24â¯nm. The characteristic 311 plane in X-ray diffraction (XRD) studies further confirmed the presence of crystalline Co3O4 on carbon frameworks. Reflection of prominent A1g peak along with D and G band in raman spectra confirmed the successful fabrication of Co3O4@MCF nanocomposite. Prepared Co3O4@MCF manifested great porosity, good biocompatibility and large surface area which allowed effective immobilization of glucose oxidase (GOx) onto its surface using chitosan (Chi) as a binder. Thus, a nanocomposite (Co3O4@MCF-Chi-GOx) modified glassy carbon electrode (GCE) was fabricated for highly selective detection of glucose using amperometry and cyclic voltammetry. The Co3O4@MCF-Chi-GOx/GCE electrode exhibited excellent biosensing performance for glucose monitoring with detection limit of (LOD) of 107.70⯵M and reproducibility of 4.7% RSD. Moreover, the biosensor holds great promise for its effective implications in point-of-care diagnostics of small biomolecules.
Key words
Full text:
1
Database:
MEDLINE
Main subject:
Blood Glucose
/
Carbon
/
Cobalt
/
Metal Nanoparticles
Language:
En
Year:
2019
Type:
Article