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Structural identification of a hotspot on CFTR for potentiation.
Liu, Fangyu; Zhang, Zhe; Levit, Anat; Levring, Jesper; Touhara, Kouki K; Shoichet, Brian K; Chen, Jue.
Affiliation
  • Liu F; Laboratory of Membrane Biophysics and Biology, The Rockefeller University, New York, NY 10065, USA.
  • Zhang Z; Tri-Institutional Training Program in Chemical Biology, The Rockefeller University, New York, NY 10065, USA.
  • Levit A; Laboratory of Membrane Biophysics and Biology, The Rockefeller University, New York, NY 10065, USA.
  • Levring J; Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, CA 94158, USA.
  • Touhara KK; Laboratory of Membrane Biophysics and Biology, The Rockefeller University, New York, NY 10065, USA.
  • Shoichet BK; Laboratory of Molecular Neurobiology and Biophysics, The Rockefeller University, New York, NY 10065, USA.
  • Chen J; Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, CA 94158, USA.
Science ; 364(6446): 1184-1188, 2019 06 21.
Article in En | MEDLINE | ID: mdl-31221859
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Full text: 1 Database: MEDLINE Main subject: Pyrans / Pyrazoles / Drugs, Investigational / Quinolones / Cystic Fibrosis Transmembrane Conductance Regulator / Chloride Channel Agonists / Aminophenols Type of study: Diagnostic_studies Limits: Humans Language: En Year: 2019 Type: Article
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Full text: 1 Database: MEDLINE Main subject: Pyrans / Pyrazoles / Drugs, Investigational / Quinolones / Cystic Fibrosis Transmembrane Conductance Regulator / Chloride Channel Agonists / Aminophenols Type of study: Diagnostic_studies Limits: Humans Language: En Year: 2019 Type: Article